概述

  • 产品名称Anti-RASGRP 4抗体
    参阅全部 RASGRP 4 一抗
  • 描述
    兔多克隆抗体to RASGRP 4
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Cat, Pig
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 149-198 (FWATVAREGN SAQRRLGDSS DLLSPGGPGP PLPMSSPGLG KKRKVSLLFD) of Human RASGRP 4 (NP_001139679).

  • 阳性对照
    • Jurkat cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab118735 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 64 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation.
  • 组织特异性Expressed by mast cells and their progenitors (at protein level). Specifically expressed in mononuclear leukocytes. Highly expressed in myeloid cells compared to lymphoid cells. Also detected in heart, skeletal muscle, spleen, liver, placenta and lung. Not detected in brain. Isoform 1 is the major isoform in normal individuals. Isoform 2 is more significantly expressed in a patient with asthma. Isoform 3 is more significantly expressed in a patient with asthma and a mastocytosis patient.
  • 序列相似性Belongs to the RASGRP family.
    Contains 1 EF-hand domain.
    Contains 1 N-terminal Ras-GEF domain.
    Contains 1 phorbol-ester/DAG-type zinc finger.
    Contains 1 Ras-GEF domain.
  • 发展阶段Expressed early during development. Detected in all fetal tissues tested.
  • 结构域The phorbol-ester/DAG-type zinc finger mediates the binding and the functional activation by DAG.
  • 细胞定位Cytoplasm. Cell membrane. Recruited to membranes upon activation by DAG.
  • Information by UniProt
  • 数据库链接
  • 别名
    • GRP4_HUMAN antibody
    • Guanyl nucleotide releasing protein 4 antibody
    • RAS guanyl releasing protein 4 antibody
    • RAS guanyl-releasing protein 4 antibody
    • RASGRP4 antibody
    see all

Anti-RASGRP 4 antibody 图像

  • Anti-RASGRP 4 antibody (ab118735) at 1 µg/ml + Jurkat cell lysate at 10 µg

    Predicted band size : 64 kDa

Anti-RASGRP 4 antibody (ab118735)参考文献

ab118735 has not yet been referenced specifically in any publications.

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