概述

  • 产品名称
    Anti-RASGRP 4抗体
    参阅全部 RASGRP 4 一抗
  • 描述
    兔多克隆抗体to RASGRP 4
  • 经测试应用
    适用于: IHC-P, WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Rat, Human
  • 免疫原

    Synthetic peptide derived from an internal domain of Mouse RASGRP 4.

性能

应用

Our Abpromise guarantee covers the use of ab106188 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use at an assay dependent concentration.
WB 1/500 - 1/5000. Predicted molecular weight: 75 kDa.

靶标

  • 功能
    Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation.
  • 组织特异性
    Expressed by mast cells and their progenitors (at protein level). Specifically expressed in mononuclear leukocytes. Highly expressed in myeloid cells compared to lymphoid cells. Also detected in heart, skeletal muscle, spleen, liver, placenta and lung. Not detected in brain. Isoform 1 is the major isoform in normal individuals. Isoform 2 is more significantly expressed in a patient with asthma. Isoform 3 is more significantly expressed in a patient with asthma and a mastocytosis patient.
  • 序列相似性
    Belongs to the RASGRP family.
    Contains 1 EF-hand domain.
    Contains 1 N-terminal Ras-GEF domain.
    Contains 1 phorbol-ester/DAG-type zinc finger.
    Contains 1 Ras-GEF domain.
  • 发展阶段
    Expressed early during development. Detected in all fetal tissues tested.
  • 结构域
    The phorbol-ester/DAG-type zinc finger mediates the binding and the functional activation by DAG.
  • 细胞定位
    Cytoplasm. Cell membrane. Recruited to membranes upon activation by DAG.
  • Information by UniProt
  • 数据库链接
  • 别名
    • GRP4_HUMAN antibody
    • Guanyl nucleotide releasing protein 4 antibody
    • RAS guanyl releasing protein 4 antibody
    • RAS guanyl-releasing protein 4 antibody
    • RASGRP4 antibody
    see all

文献

ab106188 has not yet been referenced specifically in any publications.

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