Rasagiline mesylate (ab120236)

概述

  • 产品名称Rasagiline mesylate
  • 描述
    MAO-B inhibitor
  • 别名
    • Azilect
  • 生物学描述Selective, irreversible monoamine oxidase B (MAO-B) inhibitor, with anti-Parkinson activity. In cell culture (PC-12 and neuroblastoma SH-SY5Y cells) it exhibits neuroprotective and anti-apoptotic activity against several neurotoxins.
  • 纯度> 99%

性能

    Rasagiline mesylate 图像

    • ab131457 staining Bcl2 in SK-N-SH cells treated with rasagiline mesylate (ab120236), by ICC/IF. Increase in Bcl2 expression correlates with increased concentration of rasagiline mesylate, as described in literature.
      The cells were incubated at 37°C for 24h in media containing different concentrations of ab120236 (rasagiline mesylate) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab131457 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

    Rasagiline mesylate (ab120236)参考文献

    This product has been referenced in:
    • Weinreb O  et al. Genomic and proteomic study to survey the mechanism of action of the anti-Parkinson's disease drug, rasagiline compared with selegiline, in the rat midbrain. J Neural Transm 116:1457-72 (2009). Read more (PubMed: 19396396) »
    • Mandel S  et al. Mechanism of neuroprotective action of the anti-Parkinson drug rasagiline and its derivatives. Brain Res Brain Res Rev 48:379-87 (2005). Read more (PubMed: 15850677) »
    • Youdim MB & Weinstock M Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R)aminoindan-5-YL)-ethyl methyl carbamate]. Cell Mol Neurobiol 21:555-73 (2001). Read more (PubMed: 12043833) »

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