功能Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription.
组织特异性Expressed in liver, skeletal muscle, prostate, uterus, rectum, stomach, and bladder and to a lower extent in brain, kidney, pancreas, and bone marrow. Expressed in mononuclear leukocytes and megakaryocytes.
序列相似性Belongs to the small GTPase superfamily. Ras family.
翻译后修饰Palmitoylated. Palmitoylation is required for association with recycling endosome membranes and activation of TNIK.