概述

  • 产品名称Anti-RANKL抗体[IK22/5] (Biotin)
    参阅全部 RANKL 一抗
  • 描述
    大鼠单克隆抗体[IK22/5] to RANKL (Biotin)
  • 偶联物Biotin
  • 经测试应用适用于: Flow Cytmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    NSO derived recombinant Mouse RANKL.

  • 阳性对照
    • BALB/c splenocytes and Mouse RANKL transfected cells

性能

应用

Our Abpromise guarantee covers the use of ab95720 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use 0.125-0.25µg for 105-8 cells. A final volume of 100 µL is recommended for staining the cell sample.



ab18445-Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

靶标

  • 功能Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.
  • 组织特异性Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid.
  • 疾病相关Defects in TNFSF11 are the cause of osteopetrosis autosomal recessive type 2 (OPTB2) [MIM:259710]; also known as osteoclast-poor osteopetrosis. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB2 is characterized by paucity of osteoclasts, suggesting a molecular defect in osteoclast development.
  • 序列相似性Belongs to the tumor necrosis factor family.
  • 翻译后修饰The soluble form of isoform 1 derives from the membrane form by proteolytic processing (By similarity). The cleavage may be catalyzed by ADAM17.
  • 细胞定位Cytoplasm; Secreted and Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD254 antibody
    • hRANKL2 antibody
    • ODF antibody
    • OPGL antibody
    • OPTB2 antibody
    • Osteoclast differentiation factor antibody
    • Osteoprotegerin ligand antibody
    • RANKL antibody
    • Receptor activator of nuclear factor kappa B ligand antibody
    • Receptor activator of nuclear factor kappa-B ligand antibody
    • sOdf antibody
    • TNF related activation induced cytokine antibody
    • TNF-related activation-induced cytokine antibody
    • TNF11_HUMAN antibody
    • TNFSF 11 antibody
    • Tnfsf11 antibody
    • TRANCE antibody
    • Tumor necrosis factor (ligand) superfamily member 11 antibody
    • Tumor necrosis factor ligand superfamily member 11 antibody
    • Tumor necrosis factor ligand superfamily member 11, soluble form antibody
    see all

Anti-RANKL antibody [IK22/5] (Biotin) 图像

  • Staining of 3 day unstimulated (left) and 3 day ConA activated (right) BALB/c splenocytes with 0.125 µg of Biotin Rat IgG2a Isotype Control (open histogram) or 0.125 µg of ab95720 (filled histogram) followed by Streptavidin PE. Total viable cells were used for analysis.

Anti-RANKL antibody [IK22/5] (Biotin) (ab95720)参考文献

This product has been referenced in:
  • Vondenhoff MF  et al. LTbetaR signaling induces cytokine expression and up-regulates lymphangiogenic factors in lymph node anlagen. J Immunol 182:5439-45 (2009). IF . Read more (PubMed: 19380791) »
  • Kamijo S  et al. Amelioration of bone loss in collagen-induced arthritis by neutralizing anti-RANKL monoclonal antibody. Biochem Biophys Res Commun 347:124-32 (2006). Flow Cyt . Read more (PubMed: 16815304) »

See all 2 Publications for this product

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