概述

  • 产品名称Anti-RanBP3抗体
    参阅全部 RanBP3 一抗
  • 描述
    兔多克隆抗体to RanBP3
  • 经测试应用适用于: ICC/IF, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rabbit, Horse, Chicken, Guinea pig, Cow, Dog, Xenopus laevis, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Xenopus tropicalis , Platypus (Ornithorhynchus anatinus)
  • 免疫原

    Synthetic peptide corresponding to a region between residue 150 and 200 of Human RanBP3 (NP_015561.1)

  • 阳性对照
    • Human Controls: Anaplastic Thyroid Carcinoma, Breast Carcinoma, Colon Carcinoma, Linitis Plastica Stomach Cancer, Ovarian Carcinoma, Pancreatic Islet Cell Tumor, Prostate Carcinoma, Stomach Adenocarcinoma, Testicular Seminoma
      Mouse Controls: Teratoma

性能

应用

Our Abpromise guarantee covers the use of ab84672 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF 1/100.
IHC-P 1/100 - 1/500. Antigen retrieval is not essential but may optimise staining. The use of citrate buffer will enhance staining. Likely to work in frozen sections.

靶标

  • 功能Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.
  • 组织特异性Widely expressed with high levels in testis and heart.
  • 序列相似性Contains 1 RanBD1 domain.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Cytoplasm. Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DKFZp586I1520 antibody
    • Ran binding protein 3 antibody
    • Ran-binding protein 3 antibody
    • RANB3_HUMAN antibody
    • RanBP3 antibody
    see all

Anti-RanBP3 antibody 图像

  • ab84672 at 1/100 dilution staining RanBP3 in Human colon carcinoma by Immunofluorescence Formalin-fixed, Paraffin-embedded tissue. Detection: Red-fluorescent goat antirabbit IgG highly cross-adsorbed Antibody Hilyte PlusTM 555 at a dilution of 1/100.
  • ab84672 at 1/250 dilution staining RanBP3 in Human prostate carcinoma by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining
  • ab84672 at 1/250 dilution staining RanBP3 in Mouse teratoma by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining

Anti-RanBP3 antibody (ab84672)参考文献

ab84672 has not yet been referenced specifically in any publications.

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