概述

  • 产品名称Anti-RanBP3抗体
    参阅全部 RanBP3 一抗
  • 描述
    小鼠单克隆抗体to RanBP3
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: KESLAESAAA YTKATARKCL LEKVEVITGE EAESNVLQMQ CKLFVFDKTS QSWLLRHPHP SHPAVGPCLC GEQPALCPCP GLPNYRPGTP AQLGGLLVRV , corresponding to amino acids 298-397 of Human RanBP3

性能

应用

Our Abpromise guarantee covers the use of ab56341 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.
    • 组织特异性Widely expressed with high levels in testis and heart.
    • 序列相似性Contains 1 RanBD1 domain.
    • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 细胞定位Cytoplasm. Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • DKFZp586I1520 antibody
      • Ran binding protein 3 antibody
      • Ran-binding protein 3 antibody
      • RANB3_HUMAN antibody
      • RanBP3 antibody
      see all

    Anti-RanBP3 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab56341 RanBP3 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    Anti-RanBP3 antibody (ab56341)参考文献

    ab56341 has not yet been referenced specifically in any publications.

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