概述

  • 产品名称Anti-RanBP3抗体
    参阅全部 RanBP3 一抗
  • 描述
    兔多克隆抗体to RanBP3
  • 特异性Detects Ran binding protein 3 (RanBP 3) from human and rat cells.
  • 经测试应用适用于: ICC/IF, WBmore details
  • 种属反应性
    与反应: Rat, Human
    预测可用于: Mouse, Cynomolgus Monkey
  • 免疫原

    Synthetic peptide corresponding to Human RanBP3 aa 1-13.
    Sequence:

    MADLANEEKPAIA


    (Peptide available as ab4940)

  • 阳性对照
    • HeLa cell lysate. NRK cells.

性能

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应用

Our Abpromise guarantee covers the use of ab2939 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use a concentration of 10 µg/ml.

Immunofluorescence staining of RanBP 3 in NRK cells results in diffuse nuclear staining.

WB Use a concentration of 10 µg/ml. Detects a band of approximately 60 kDa (predicted molecular weight: 60 kDa).Can be blocked with RanBP3 peptide (ab4940).

靶标

  • 功能Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.
  • 组织特异性Widely expressed with high levels in testis and heart.
  • 序列相似性Contains 1 RanBD1 domain.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Cytoplasm. Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DKFZp586I1520 antibody
    • Ran binding protein 3 antibody
    • Ran-binding protein 3 antibody
    • RANB3_HUMAN antibody
    • RanBP3 antibody
    see all

Anti-RanBP3 antibody 图像

  • Immunohistochemical staining of RanBP3 in NRK cells using ab2939.


  • Predicted band size : 60 kDa


    Western blot on RanBP3 in HeLa cytosol using ab2939

Anti-RanBP3 antibody (ab2939)参考文献

This product has been referenced in:
  • Zhang R  et al. Perturbation of host nuclear membrane component RanBP2 impairs the nuclear import of human immunodeficiency virus -1 preintegration complex (DNA). PLoS One 5:e15620 (2010). WB ; Human . Read more (PubMed: 21179483) »

See 1 Publication for this product

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