概述

  • 产品名称Anti-RanBP2抗体
    参阅全部 RanBP2 一抗
  • 描述
    兔多克隆抗体to RanBP2
  • 特异性Detects Ran binding protein 2 (RanBP 2) from human and bovine retina.
  • 经测试应用适用于: IHC-P, WBmore details
  • 种属反应性
    与反应: Mouse, Cow, Human
    预测可用于: Chimpanzee
  • 免疫原

    Synthetic peptide corresponding to Human RanBP2 aa 1-18.
    Sequence:

    MRRSKADVERYIASVQGS


    (Peptide available as ab4939)

  • 阳性对照
    • Bovine retinal extracts.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab2938 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 10 µg/ml.

Immunohistochemical staining of bovine retina results in cytoplasmic staining of cells within the inner nuclear layer as well as the ganglion cells.

WB Use a concentration of 1 µg/ml. Detects a band of approximately 360 kDa (predicted molecular weight: 358 kDa).Can be blocked with RanBP2 peptide (ab4939).

Detects a band of approximately 360 kDa representing RanBP 2 from bovine retinal extracts.

靶标

  • 功能E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Could also have isomerase or chaperone activity and may bind RNA or DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1.
  • 通路Protein modification; protein sumoylation.
  • 疾病相关Defects in RANBP2 are the cause of susceptibility to encephalopathy acute necrotizing type 1 (ANE1) [MIM:608033]. A rapidly progressive encephalopathy manifesting in susceptibile individuals with seizures and coma. It can occur within days in otherwise healthy children after common viral infections such as influenza and parainfluenza, without evidence of viral infection of the brain or inflammatory cell infiltration. Brain T2-weighted magnetic resonance imaging reveals characteristic symmetric lesions present in the thalami, pons and brainstem.
  • 序列相似性Contains 1 PPIase cyclophilin-type domain.
    Contains 4 RanBD1 domains.
    Contains 8 RanBP2-type zinc fingers.
    Contains 1 TPR repeat.
  • 结构域Contains F-X-F-G repeats.
  • 翻译后修饰Polyubiquitinated by PARK2, which leads to proteasomal degradation.
  • 细胞定位Nucleus > nuclear pore complex. Cytoplasmic filaments.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 358 kDa nucleoporin antibody
    • ANE1 antibody
    • E3 SUMO-protein ligase RanBP2 antibody
    • IIAE3 antibody
    • Nuclear pore complex protein Nup358 antibody
    • Nucleoporin 358 antibody
    • Nucleoporin Nup358 antibody
    • NUP358 antibody
    • p270 antibody
    • RAN binding protein 2 antibody
    • Ran-binding protein 2 antibody
    • RANBP2 antibody
    • RBP2_HUMAN antibody
    • Transformation related protein 2 antibody
    • TRP 1 antibody
    • TRP 2 antibody
    • TRP1 antibody
    • TRP2 antibody
    see all

Anti-RanBP2 antibody 图像

  • Immunohistochemical staining of RanBP2 in bovine retina using ab2938.



  • Predicted band size : 358 kDa
    Western blot of RanBP2 from human retinal extracts using ab2938. Western blot of RanBP2 from human retinal extracts using ab2938.

Anti-RanBP2 antibody (ab2938)参考文献

This product has been referenced in:
  • Ocwieja KE  et al. HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2. PLoS Pathog 7:e1001313 (2011). WB ; Human . Read more (PubMed: 21423673) »
  • Nagai M  et al. Mice lacking Ran binding protein 1 are viable and show male infertility. FEBS Lett 585:791-6 (2011). IHC ; Mouse . Read more (PubMed: 21310149) »

See all 6 Publications for this product

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"