Anti-RanBP2抗体[2E1] (ab111811)

概述

  • 产品名称Anti-RanBP2抗体[2E1]
    参阅全部 RanBP2 一抗
  • 描述
    小鼠单克隆抗体[2E1] to RanBP2
  • 经测试应用适用于: IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Recombinant protein corresponding to 150 N terminal residues of Human RanBP2.

性能

应用

Our Abpromise guarantee covers the use of ab111811 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/100.
ICC/IF 1/20 - 1/200.

靶标

  • 功能E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Could also have isomerase or chaperone activity and may bind RNA or DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1.
  • 通路Protein modification; protein sumoylation.
  • 疾病相关Defects in RANBP2 are the cause of susceptibility to encephalopathy acute necrotizing type 1 (ANE1) [MIM:608033]. A rapidly progressive encephalopathy manifesting in susceptibile individuals with seizures and coma. It can occur within days in otherwise healthy children after common viral infections such as influenza and parainfluenza, without evidence of viral infection of the brain or inflammatory cell infiltration. Brain T2-weighted magnetic resonance imaging reveals characteristic symmetric lesions present in the thalami, pons and brainstem.
  • 序列相似性Contains 1 PPIase cyclophilin-type domain.
    Contains 4 RanBD1 domains.
    Contains 8 RanBP2-type zinc fingers.
    Contains 1 TPR repeat.
  • 结构域Contains F-X-F-G repeats.
  • 翻译后修饰Polyubiquitinated by PARK2, which leads to proteasomal degradation.
  • 细胞定位Nucleus > nuclear pore complex. Cytoplasmic filaments.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 358 kDa nucleoporin antibody
    • ANE1 antibody
    • E3 SUMO-protein ligase RanBP2 antibody
    • IIAE3 antibody
    • Nuclear pore complex protein Nup358 antibody
    • Nucleoporin 358 antibody
    • Nucleoporin Nup358 antibody
    • NUP358 antibody
    • p270 antibody
    • RAN binding protein 2 antibody
    • Ran-binding protein 2 antibody
    • RANBP2 antibody
    • RBP2_HUMAN antibody
    • Transformation related protein 2 antibody
    • TRP 1 antibody
    • TRP 2 antibody
    • TRP1 antibody
    • TRP2 antibody
    see all

Anti-RanBP2 antibody [2E1] (ab111811)参考文献

ab111811 has not yet been referenced specifically in any publications.

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