功能Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane.
序列相似性Belongs to the RANBP1 family. Contains 1 RanBD1 domain.
ab97659 at 1/200 dilution staining RanBP1 in HeLa cells by Immunofluorescence, Paraformaldehyde fixed. Lower image is merged with DNA probe.
Anti-RanBP1 antibody (ab97659)参考文献
This product has been referenced in:
Neggers JE et al. Identifying drug-target selectivity of small-molecule CRM1/XPO1 inhibitors by CRISPR/Cas9 genome editing. Chem Biol22:107-16 (2015).
Read more (PubMed: 25579209) »
Hwang HI et al. Phosphorylation of Ran-binding Protein-1 by Polo-like Kinase-1 Is Required for Interaction with Ran and Early Mitotic Progression. J Biol Chem286:33012-20 (2011).
Read more (PubMed: 21813642) »