Anti-RALB抗体[4D1] (ab117742)

概述

  • 产品名称Anti-RALB抗体[4D1]
    参阅全部 RALB 一抗
  • 描述
    小鼠单克隆抗体[4D1] to RALB
  • 经测试应用适用于: WB, IP, IHC-P, Sandwich ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant protein of Human RALB (NP_002872.1).

  • 阳性对照
    • Recombinant Human RALB protein;, RALB transfected 293T cell lysate, Human Spleen tissue.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab117742 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 23 kDa.
IP Use at an assay dependent concentration. (40 ug of antibody per 100 ul of beads)
IHC-P Use a concentration of 5 µg/ml.
Sandwich ELISA Use at an assay dependent concentration.

靶标

  • 功能Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Plays a role in the late stages of cytokinesis and is required for the abscission of the bridge joining the sister cells emerging from mitosis. Required for suppression of apoptosis.
  • 序列相似性Belongs to the small GTPase superfamily. Ras family.
  • 翻译后修饰Prenylation is essential for membrane localization. The geranylgeranylated form and the farnesylated mutant does not undergo alternative prenylation in response to geranylgeranyltransferase I inhibitors (GGTIs) and farnesyltransferase I inhibitors (FTIs).
  • 细胞定位Cell membrane. During late cytokinesis localizes at the midbody.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 5730472O18Rik antibody
    • dRalb antibody
    • GTP binding protein antibody
    • Ralb antibody
    • RALB_HUMAN antibody
    • RAS like protein B antibody
    • Ras related GTP binding protein B antibody
    • Ras-related protein Ral-B antibody
    • v ral simian leukemia viral oncogene homolog B (ras related GTP binding protein) antibody
    • v ral simian leukemia viral oncogene homolog B (ras related) antibody
    • V ral simian leukemia viral oncogene homolog B antibody
    see all

Anti-RALB antibody [4D1] 图像

  • All lanes : Anti-RALB antibody [4D1] (ab117742)

    Lane 1 : 293T cell lysate, transfected with RALB
    Lane 2 : 293T cell lysate, non-transfected


    Predicted band size : 23 kDa
  • ab117742, at 5 µg/ml, staining RALB in Formalin-fixed, Paraffin-embedded Human Spleen tissue by Immunohistochem
  • Detection limit for recombinant tagged RALB is approximately 0.3ng/ml (ab117742) as a capture antibody.

Anti-RALB antibody [4D1] (ab117742)参考文献

ab117742 has not yet been referenced specifically in any publications.

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