Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Tissue culture supernatant
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/1000. Detects a band of approximately 23 kDa (predicted molecular weight: 23 kDa).
1/100 - 1/250.
ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.
1/50 - 1/100. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex.
Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney.
Contains 1 CARD domain.
Contains 1 death domain.
Contains a death domain involved in the binding of RIP protein.
The CARD domain mediates the interaction with caspase-2.
Information by UniProt
CASP2 and RIPK1 domain containing adaptor with death domain antibody
Caspase and RIP adapter with death domain antibody
Caspase and RIP adaptor with death domain antibody
Anti-RAIDD antibody [EPR1640Y] 图像
Western blot - RAIDD antibody [EPR1640Y] (ab52621)
Anti-RAIDD antibody [EPR1640Y] (ab52621) at 1/1000 dilution + HeLa cell lysate at 10 µg
Secondary goat anti-rabbit HRP at 1/2000 dilution Predicted band size : 23 kDa Observed band size : 23 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RAIDD antibody [EPR1640Y] (ab52621)
ab52621, at a 1/50 dilution, staining Human RAIDD in heart muscle, using Immunohistochemistry, Paraffin embedded tissue.
Anti-RAIDD antibody [EPR1640Y] (ab52621)参考文献
This product has been referenced in:
Di Donato N
et al. Mutations in CRADD Result in Reduced Caspase-2-Mediated Neuronal Apoptosis and Cause Megalencephaly with a Rare Lissencephaly Variant. Am J Hum Genet 99:1117-1129 (2016).
Read more (PubMed: 27773430) »
et al. Regulation of CRADD-caspase 2 cascade by histone deacetylase 1 in gastric cancer. Am J Transl Res 6:538-47 (2014).
Read more (PubMed: 25360218) »
See all 3 Publications
for this product
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"