• 产品名称Anti-RAGE抗体
    参阅全部 RAGE 一抗
  • 描述
    兔多克隆抗体to RAGE
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    A synthetic peptide corresponding to a sequence mapping in the middle region of human advanced glycosylation end-product-specific receptor(RAGE), different from the mouse and rat sequence by two amino acids.

  • 阳性对照
    • Rat lung tissue and lysate



Our Abpromise guarantee covers the use of ab65965 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
  • 应用说明ICC: Use at a concentration of 0.5 - 1 µg/ml.
    IHC-P: Use at a concentration of 0.5 - 1 µg/ml.
    WB: Use at a concentration of 1 - 2 µg/ml. Detects a band of approximately 48 kDa (predicted molecular weight: 48 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space.
    • 组织特异性Endothelial cells.
    • 序列相似性Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    • 细胞定位Secreted and Cell membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Advanced glycosylation end product-specific receptor antibody
      • Ager antibody
      • MGC2235 antibody
      • RAGE_HUMAN antibody
      • Receptor for advanced glycosylation end products antibody
      see all

    Anti-RAGE antibody 图像

    • Immunohistochemical analysis of paraffin-embedded Rat lung tissue sections using ab65965 at 1µg/ml
    • Anti-RAGE antibody (ab65965) at 2 µg/ml + Rat lung tissue lysate

      Predicted band size : 48 kDa
      Observed band size : 48 kDa

    Anti-RAGE antibody (ab65965)参考文献

    ab65965 has not yet been referenced specifically in any publications.

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