概述

  • 产品名称Anti-Radixin抗体
    参阅全部 Radixin 一抗
  • 描述
    山羊多克隆抗体to Radixin
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Dog
  • 免疫原

    Synthetic peptide (

    C-QARDETKKTQND

    ) from an internal region of Human Radixin.

  • 阳性对照
    • WB: Human tonsil, lymph node and spleen lysates IHC-P: Human kidney and placenta tissue

性能

应用

Our Abpromise guarantee covers the use of ab111064 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 69 kDa.
IHC-P Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.
  • 疾病相关Defects in RDX are the cause of deafness autosomal recessive type 24 (DFNB24) [MIM:611022]. DFNB24 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
  • 序列相似性Contains 1 FERM domain.
  • 结构域The N-terminal domain interacts with the C-terminal domain of LAYN. An interdomain interaction between its N-terminal and C-terminal domains inhibits its ablilty to bind LAYN. In the presence of acidic phospholipids, the interdomain interaction is inhibited and this enhances binding to LAYN.
  • 翻译后修饰Phosphorylated by tyrosine-protein kinases.
  • 细胞定位Cell membrane. Cytoplasm > cytoskeleton. Cleavage furrow. Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CB567 antibody
    • CG12537 antibody
    • DFNB24 antibody
    • ESP10 antibody
    • Hh-induced MATH and BTB domain-containing protein antibody
    • HIB antibody
    • Moesin-B antibody
    • Protein roadkill antibody
    • RADI_HUMAN antibody
    • Radixin antibody
    • RDX antibody
    see all

Anti-Radixin antibody 图像

  • ab111064, at 2.5 µg/ml, staining Radixin in formalin-fixed, paraffin-embedded Human kidney tissue.
  • ab111064, at 2.5 µg/ml, staining Radixin in formalin-fixed, paraffin-embedded Human placenta tissue.
  • Anti-Radixin antibody (ab111064) at 0.03 µg/ml + Human Tonsil lysate (in RIPA buffer) at 35 µg/ml

    Predicted band size : 69 kDa

Anti-Radixin antibody (ab111064)参考文献

ab111064 has not yet been referenced specifically in any publications.

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