概述

  • 产品名称Anti-Rad51L1抗体[EPR5728]
    参阅全部 Rad51L1 一抗
  • 描述
    兔单克隆抗体[EPR5728] to Rad51L1
  • 经测试应用适用于: WB, ICC/IFmore details
    不适用于: Flow Cyt,IHC-P or IP
  • 种属反应性
    与反应: Human
    不与反应: Mouse, Rat
  • 免疫原

    Synthetic peptide corresponding to N-terminal amino acids of Human Rad51L1.

  • 阳性对照
    • MCF7 cell lysate; MCF7 cells.
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

性能

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应用

Our Abpromise guarantee covers the use of ab124675 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Detects a band of approximately 42 kDa (predicted molecular weight: 42 kDa).
ICC/IF 1/50 - 1/100.
  • 应用说明Is unsuitable for Flow Cyt,IHC-P or IP.
  • 靶标

    • 功能Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. The RAD51B-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.
    • 组织特异性Expressed in a wide range of tissues.
    • 疾病相关Note=A chromosomal aberration involving RAD51L1 is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with HMGA1.
      Note=A chromosomal aberration involving RAD51L1 is found in uterine leiomyoma. Translocation t(12;14)(q15;q23-24) with HMGA2.
    • 序列相似性Belongs to the RecA family. RAD51 subfamily.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • DNA repair protein RAD51 homolog 2 antibody
      • hREC2 antibody
      • MGC34245 antibody
      • OTTHUMP00000212251 antibody
      • OTTHUMP00000212253 antibody
      • OTTHUMP00000212254 antibody
      • OTTHUMP00000212255 antibody
      • R51H2 antibody
      • RA51B_HUMAN antibody
      • RAD51 homolog B (S. cerevisiae) antibody
      • RAD51 homolog B antibody
      • RAD51 like 1 antibody
      • RAD51 like protein 1 antibody
      • RAD51-like protein 1 antibody
      • Rad51B antibody
      • RAD51L1 antibody
      • REC2 antibody
      • RecA like protein antibody
      • Recombination repair protein antibody
      see all

    Anti-Rad51L1 antibody [EPR5728] 图像

    • Anti-Rad51L1 antibody [EPR5728] (ab124675) at 1/1000 dilution + MCF7 cell lysate at 10 µg

      Secondary
      Goat anti-Rabbit HRP at 1/2000 dilution

      Predicted band size : 42 kDa
    • ab124675, at 1/50 dilution, staining Rad51L1 in MCF7 cells by Immunofluorescence.
    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    Anti-Rad51L1 antibody [EPR5728] (ab124675)参考文献

    This product has been referenced in:
    • Lee PS  et al. RAD51B Activity and Cell Cycle Regulation in Response to DNA Damage in Breast Cancer Cell Lines. Breast Cancer (Auckl) 8:135-44 (2014). WB ; Human . Read more (PubMed: 25368520) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"