概述

  • 产品名称Anti-Rad51C抗体
    参阅全部 Rad51C 一抗
  • 描述
    兔多克隆抗体to Rad51C
  • 经测试应用适用于: WB, IPmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Synthetic peptide:

    RELVGYPLSPAVRGKGKLVAAGFQTAED

    , corresponding to N terminal amino acids 3-28 of Mouse Rad51C

  • 阳性对照
    • Mouse embryonic fibroblasts / Irradiated cells.

性能

应用

Our Abpromise guarantee covers the use of ab95201 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent dilution. Predicted molecular weight: 42 kDa.
IP Use at an assay dependent dilution.

靶标

  • 功能Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. The RAD51B-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Participates in branch migration and Holliday junction resolution and thus is important for processing HR intermediates late in the DNA repair process. Also has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis.
  • 组织特异性Expressed in a variety of tissues, with highest expression in testis, heart muscle, spleen and prostate.
  • 疾病相关Defects in RAD51C are the cause of Fanconi anemia complementation group O (FANCO) [MIM:613390]. It is a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
    Defects in RAD51C are the cause of breast-ovarian cancer familial type 3 (BROVCA3) [MIM:613399]. It is a condition associated with familial predisposition to cancer of the breast and ovaries. Characteristic features in affected families are an early age of onset of breast cancer (often before age 50), increased chance of bilateral cancers (cancer that develop in both breasts, or both ovaries, independently), frequent occurrence of breast cancer among men, increased incidence of tumors of other specific organs, such as the prostate.
  • 序列相似性Belongs to the RecA family. RAD51 subfamily.
  • 细胞定位Nucleus. Cytoplasm. Cytoplasm > perinuclear region. Mitochondrion. DNA damage induces an increase in nuclear levels. Accumulates in DNA damage induced nuclear foci or RAD51C foci which is formed during the S or G2 phase of cell cycle. Accumulation at DNA lesions requires the presence of NBN/NBS1, ATM and RPA.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BROVCA3 antibody
    • DNA repair protein RAD51 homolog 3 antibody
    • FANCO antibody
    • MGC104277 antibody
    • R51H3 antibody
    • RA51C_HUMAN antibody
    • Rad 51C antibody
    • RAD51 homolog C (S. cerevisiae) antibody
    • Rad51 homolog c (S. cerevisiae), isoform CRA_b antibody
    • RAD51 homolog C antibody
    • RAD51 like protein 2 antibody
    • RAD51 paralog C antibody
    • RAD51, S. cerevisiae, homolog of, C antibody
    • RAD51-like protein 2 antibody
    • RAD51C antibody
    • RAD51C protein antibody
    • RAD51L2 antibody
    • RAD51L2/RAD51C protein antibody
    • RGD1563765 antibody
    • Yeast RAD51 homolog 3 antibody
    see all

Anti-Rad51C antibody (ab95201)参考文献

ab95201 has not yet been referenced specifically in any publications.

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