概述

  • 产品名称Anti-RAC抗体[23A8]
  • 描述
    小鼠单克隆抗体[23A8] to RAC
  • 特异性ab13048 recognizes Rac1 with a slight Rac2 cross-reactivity.
  • 经测试应用适用于: IHC-Fr, IP, WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Recombinant full length Human RAC1.

  • 常规说明Storage in frost-free freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

性能

应用

Our Abpromise guarantee covers the use of ab13048 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-Fr Use a concentration of 10 µg/ml.
IP Use at an assay dependent concentration.
WB Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 21 kDa.

靶标

  • 相关性RAC, a small GTPase in the ras family, regulates the formation of membrane ruffles, lamellipodia and filopodia. It is involved in cytoskeletal actin organization and transformation. The p21 activated kinases (PAKs) are direct targets of active Rac and Cdc42 which can induce the assembly of polarized cytoskeletal structures when expressed in fibroblasts. RAC1 and RAC2 are also essential components of NADPH oxidase, the enzyme responsible for generating free radicals.
  • 细胞定位Cell Membrane
  • 数据库链接
  • 别名
    • MIG5 antibody
    • Migration inducing gene 5 antibody
    • p21 Rac1 antibody
    • RAC1 antibody
    • Ras like protein TC25 antibody
    see all

Anti-RAC antibody [23A8] (ab13048)参考文献

This product has been referenced in:
  • Ghosh S  et al. Endoplasmic Reticulum Resident Heat Shock Protein 90 (Hsp90) Isoform Glucose-Regulated Protein 94 (Grp94) Regulates Cell Polarity and Cancer Cell Migration by Affecting Intracellular Transport. J Biol Chem N/A:N/A (2016). WB ; Human . Read more (PubMed: 26872972) »
  • Zhang X  et al. Digital gene expression tag profiling analysis of the gene expression patterns regulating the early stage of mouse spermatogenesis. PLoS One 8:e58680 (2013). WB ; Mouse . Read more (PubMed: 23554914) »

See all 5 Publications for this product

Product Wall

Thank you for your enquiry. Unfortunately this antibody has not been tested for specificity between the different RAC isoforms. I hope this information helps, please do not hesitate to contact us if you need any more advice or information.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"