概述

  • 产品名称
  • 描述
    兔多克隆抗体to RAB7L1
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow
  • 免疫原

    Recombinant protein fragment containing a sequence corresponding to a region within amino acids 53 and 199 of RAB7L1 (AAH02585).

  • 阳性对照
    • A431 and Raji cell lysates

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 20% Glycerol, 1% BSA, PBS, pH 7.0
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab101394 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 23 kDa.

靶标

  • 功能
    Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection.
  • 组织特异性
    Ubiquitous.
  • 序列相似性
    Belongs to the small GTPase superfamily. Rab family.
  • 翻译后修饰
    In case of Salmonella enterica serovar Typhimurium (S.Typhimurium) infection, is proteolytically cleaved between Gly-41 and Val-42 by the GtgE viral protease encoded on the Gifsy-2 lysogen bacteriophage, which therefore prevents the recruitment of RAB29 to S.Typhimurium-containing vacuoles. In contrast, no proteolytically cleavage is detected in S.Typhi-infected cells (PubMed:22042847).
  • 细胞定位
    Cell membrane. Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network. Vacuole. Cytoplasm, cytoskeleton. Colocalizes with LRRK2 along tubular structures emerging from Golgi apparatus (By similarity). Colocalizes with GM130 at the Golgi apparatus. Colocalizes with dynamic tubules emerging from and retracting to the Golgi apparatus. Colocalizes with TGN46 at the trans-Golgi network (TGN). In Salmonella enterica serovar Typhi (S.Typhi) infected epithelial cells, is recruited and colocalized with both S.Typhi-containing vacuoles and dynamic tubules as well as those emerging from the vacuole toward the cell periphery.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DKFZp686P1051 antibody
    • Rab 7 like protein 1 antibody
    • RAB 7L antibody
    • Rab-7-like protein 1 antibody
    • RAB29 antibody
    • Rab7 like protein 1 antibody
    • RAB7 member RAS oncogene family like 1 antibody
    • RAB7L antibody
    • RAB7L_HUMAN antibody
    • Ras related protein Rab 7L1 antibody
    • Ras related protein Rab7L1 antibody
    • Ras-related protein Rab-29 antibody
    • Ras-related protein Rab-7L1 antibody
    see all

图片

  • Anti-RAB7L1 antibody (ab101394) at 1/500 dilution + A431 whole cell lysate at 30 µg

    Predicted band size : 23 kDa

实验方案

文献

ab101394 has not yet been referenced specifically in any publications.

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