概述

  • 产品名称Anti-RAB7B抗体
    参阅全部 RAB7B 一抗
  • 描述
    小鼠单克隆抗体to RAB7B
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: DIWRGDVLAK IVPMEQSYPM VLLGNKIDLA DRKVPQEVAQ GWCREKDIPY FEVSAKNDIN VVQAFEMLAS RALSRYQSIL ENHLTESIKL SPDQSRSRCC , corresponding to amino acids 100-200 of Human RAB7B.

  • 阳性对照
    • A431, HL60 cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab58029 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IHC-P
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.
    • 组织特异性Expressed in heart, placenta, lung, skeletal muscle and peripheral blood leukocyte.
    • 序列相似性Belongs to the small GTPase superfamily. Rab family.
    • 细胞定位Late endosome. Lysosome. Golgi apparatus > trans-Golgi network. Golgi apparatus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • MGC16212 antibody
      • MGC9726 antibody
      • RAB7 antibody
      • rab7B antibody
      • RAB7B, member RAS oncogene family antibody
      • RAB7B_HUMAN antibody
      • Ras related protein Rab 7b antibody
      • Ras-related protein Rab-7B antibody
      see all

    Anti-RAB7B antibody 图像

    • RAB7 antibody (ab58029) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human small Intestine.


    • Predicted band size : 23 kDa

    Anti-RAB7B antibody (ab58029)参考文献

    ab58029 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab58029.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"