概述

  • 产品名称Anti-RAB7B抗体
    参阅全部 RAB7B 一抗
  • 描述
    兔多克隆抗体to RAB7B
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length Human RAB7B (AAH17092.1; amino acids 1-199)

  • 阳性对照
    • Human liver tissue lysate, RAB7B transfected 293T cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab103544 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 23 kDa.

靶标

  • 功能Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.
  • 组织特异性Expressed in heart, placenta, lung, skeletal muscle and peripheral blood leukocyte.
  • 序列相似性Belongs to the small GTPase superfamily. Rab family.
  • 细胞定位Late endosome. Lysosome. Golgi apparatus > trans-Golgi network. Golgi apparatus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • MGC16212 antibody
    • MGC9726 antibody
    • RAB7 antibody
    • rab7B antibody
    • RAB7B, member RAS oncogene family antibody
    • RAB7B_HUMAN antibody
    • Ras related protein Rab 7b antibody
    • Ras-related protein Rab-7B antibody
    see all

Anti-RAB7B antibody 图像

  • Anti-RAB7B antibody (ab103544) at 1 µg/ml + Human liver tissue lysate at 50 µg

    Predicted band size : 23 kDa
  • All lanes : Anti-RAB7B antibody (ab103544) at 1 µg/ml

    Lane 1 : RAB7B transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 23 kDa

Anti-RAB7B antibody (ab103544)参考文献

ab103544 has not yet been referenced specifically in any publications.

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