概述

  • 产品名称Anti-RAB3IP抗体
    参阅全部 RAB3IP 一抗
  • 描述
    兔多克隆抗体to RAB3IP
  • 经测试应用适用于: ICC/IF, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 108-157 (PCSTSGVTAG LTKLTTRKDN YNAEREFLQG ATITEACDGS DDIFGLSTDS) of Human RAB3IP (NP_783322).

  • 阳性对照
    • NCI-H226 cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab94455 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF 1/200.
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 53 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis.
  • 组织特异性Expressed in brain, kidney, heart, pancreas and placenta. Not detected in skeletal muscle or liver.
  • 序列相似性Belongs to the SEC2 family.
  • 细胞定位Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Predominantly cytoplasmic but a small proportion colocalizes with SSX2 in the nucleus. Activation of protein kinase C results in redistribution to the periphery of lamellipodia. In the cytoskeleton, localizes to cortical actin.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Gtpat12 antibody
    • Rab-3A-interacting protein antibody
    • RAB3A interacting protein antibody
    • RAB3A interacting protein (rabin3) antibody
    • RAB3A interacting protein antibody
    • RAB3A-interacting protein antibody
    • RAB3I_HUMAN antibody
    • Rab3ip antibody
    • Rabin 3 antibody
    • Rabin-3 antibody
    • RABIN3 antibody
    • RABIN3, rat, homolog of antibody
    • Rabin8 antibody
    • SSX2 interacting protein antibody
    • SSX2 interacting protein antibody
    • SSX2-interacting protein antibody
    see all

Anti-RAB3IP antibody 图像

  • Species + tissue type: Mouse retina tissue. Primary antibody dilution: 1:200. Secondary antibody: Goat anti-rabbit Alexafluor 568. Secondary antibody dilution: 1:200

  • Anti-RAB3IP antibody (ab94455) at 1 µg/ml (in 5% skim milk / PBS buffer) + NCI-H226 cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 53 kDa
    Gel concentration: 12%

Anti-RAB3IP antibody (ab94455)参考文献

ab94455 has not yet been referenced specifically in any publications.

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