概述

  • 产品名称Anti-RAB3GAP1抗体
    参阅全部 RAB3GAP1 一抗
  • 描述
    兔多克隆抗体to RAB3GAP1
  • 特异性ab74447 detects endogenous levels of total RAB3GAP1 protein. Does not react with mouse samples, by honology and testing for NIH3T3
  • 经测试应用适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    不与反应: Mouse
  • 免疫原

    Synthetic peptide derived from an internal region of human RAB3GAP1.

  • 阳性对照
    • Human testis tissue; 293 cell extracts.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab74447 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 111 kDa.
ELISA 1/40000.
IHC-P 1/50 - 1/100.

靶标

  • 功能Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.
  • 组织特异性Ubiquitous.
  • 疾病相关Defects in RAB3GAP1 are the cause of Warburg micro syndrome type 1 (WARBM1) [MIM:600118]. A rare syndrome characterized by microcephaly, microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus callosum hypoplasia, severe mental retardation, spastic diplegia, and hypogonadism.
  • 序列相似性Belongs to the Rab3-GAP catalytic subunit family.
  • 细胞定位Cytoplasm. In neurons, it is enriched in the synaptic soluble fraction.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DKFZp434A012 antibody
    • KIAA0066 antibody
    • P130 antibody
    • Rab3 GAP antibody
    • Rab3 GAP p130 antibody
    • RAB3 GTPase activating protein 130 kDa subunit antibody
    • Rab3 GTPase activating protein catalytic subunit antibody
    • RAB3 GTPase activating protein subunit 1 (catalytic) antibody
    • RAB3 GTPase-activating protein 130 kDa subunit antibody
    • Rab3 GTPase-activating protein catalytic subunit antibody
    • Rab3-GAP antibody
    • Rab3-GAP p130 antibody
    • RAB3GAP antibody
    • rab3gap1 antibody
    • RAB3GAP130 antibody
    • RB3GP_HUMAN antibody
    • WARBM1 antibody
    see all

Anti-RAB3GAP1 antibody 图像

  • ab74447, at a 1/50 dilution, staining RAB3GAP1 in paraffin embedded human testis tissue by Immunohistochemistry in the absence (left image) or presence (right image) of the immunizing peptide.
  • All lanes : Anti-RAB3GAP1 antibody (ab74447) at 1/500 dilution

    Lane 1 : 293 cell extracts
    Lane 2 : 293 cell extracts with immunizing peptide at 10 µg

    Lysates/proteins at 5 µg per lane.


    Predicted band size : 111 kDa
    Observed band size : 111 kDa

Anti-RAB3GAP1 antibody (ab74447)参考文献

ab74447 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab74447.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"