概述

  • 产品名称Anti-RAB27A抗体
    参阅全部 RAB27A 一抗
  • 描述
    兔多克隆抗体to RAB27A
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Recombinant fragment, corresponding to amino acids 1-215 of Human RAB27A (BC132800).

  • 阳性对照
    • HEK293 cell lysate; Human fetal skin lysate.

性能

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应用

Our Abpromise guarantee covers the use of ab124325 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 25 kDa.

靶标

  • 功能Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.
  • 组织特异性Found in all the examined tissues except in brain. Low expression was found in thymus, kidney, muscle and placenta. Detected in melanocytes, and in most tumor cell lines examined. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells.
  • 疾病相关Defects in RAB27A are a cause of Griscelli syndrome type 2 (GS2) [MIM:607624]. Griscelli syndrome is a rare autosomal recessive disorder that results in pigmentary dilution of the skin and hair, the presence of large clumps of pigment in hair shafts, and an accumulation of melanosomes in melanocytes. GS2 patients also develop an uncontrolled T-lymphocyte and macrophage activation syndrome, known as hemophagocytic syndrome, leading to death in the absence of bone marrow transplantation. Neurological impairment is present in some patients, likely as a result of hemophagocytic syndrome.
  • 序列相似性Belongs to the small GTPase superfamily. Rab family.
  • 细胞定位Membrane. Melanosome. Late endosome. Lysosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes to endosomal exocytic vesicles.
  • Information by UniProt
  • 数据库链接
  • 别名
    • GS2 antibody
    • GTP-binding protein Ram antibody
    • HsT18676 antibody
    • MGC117246 antibody
    • Mutant Ras related protein Rab-27A antibody
    • Rab-27 antibody
    • RAB-27A antibody
    • RAB27 antibody
    • RAB27A antibody
    • RAB27A member RAS oncogene family antibody
    • RAM antibody
    • Ras-related protein Rab-27A antibody
    • Ras-related protein Rab27A antibody
    • RB27A_HUMAN antibody
    see all

Anti-RAB27A antibody 图像

  • All lanes : Anti-RAB27A antibody (ab124325) at 1/500 dilution

    Lane 1 : HEK293 cell lysate.
    Lane 2 : Human fetal skin lysate.


    Predicted band size : 25 kDa

Anti-RAB27A antibody (ab124325)参考文献

ab124325 has not yet been referenced specifically in any publications.

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