(R)-(-)-Deprenyl hydrochloride (Selegiline hydrochloride) (ab120604)

概述

  • 产品名称(R)-(-)-Deprenyl hydrochloride (Selegiline hydrochloride)
  • 描述
    MAO-B selective inhibitor
  • 别名
    • Selegiline hydrochloride
  • 生物学描述Selective and irreversible MAO-B inhibitor (IC50 = 6.8 nM). Elicits neuroprotective and neuronal rescue activity. Alleviates oxidative stress.
  • 纯度> 99%

性能

    (R)-(-)-Deprenyl hydrochloride (Selegiline hydrochloride) 图像

    • ab692 staining Bcl2 in SK-N-SH cells treated with (R)-(-)-Deprenyl hydrochloride (Selegiline hydrochloride) (ab120604), by ICC/IF. Increase of Bcl2 expression correlates with increased concentration of (R)-(-)-Deprenyl hydrochloride (Selegiline hydrochloride), as described in literature.
      The cells were incubated at 37°C for 3h in media containing different concentrations of ab120604 ((R)-(-)-Deprenyl hydrochloride (Selegiline hydrochloride)) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab692 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

    (R)-(-)-Deprenyl hydrochloride (Selegiline hydrochloride) (ab120604)参考文献

    This product has been referenced in:
    • Magyar K  et al. R-deprenyl: pharmacological spectrum of its activity. Neurochem Res 35:1922-32 (2010). Read more (PubMed: 20725780) »
    • Yasar S  et al. Metabolic transformation plays a primary role in the psychostimulant-like discriminative-stimulus effects of selegiline [(R)-(-)-deprenyl]. J Pharmacol Exp Ther 317:387-94 (2006). Read more (PubMed: 16352699) »
    • Mukherjee J  et al. N-(6-18F-fluorohexyl)-N-methylpropargylamine: a fluorine-18-labeled monoamine oxidase B inhibitor for potential use in PET studies. Nucl Med Biol 26:111-6 (1999). Read more (PubMed: 10096510) »

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