R-(-)-α-Methylhistamine dihydrobromide (ab120774)

概述

  • 产品名称
    R-(-)-α-Methylhistamine dihydrobromide
  • 描述
    Highly potent, selective H3 receptor agonist
  • 生物学描述
    Highly potent, selective H3 receptor agonist (Kd = 50 nM). Induces H4-mediated eosinophil shape change (EC50 = 66 nM). Inhibits H3-mediated histamine synthesis and release in the CNS. Active in vivo.
  • 纯度
    > 99%

性能

  • 化学名称
    1-(1H-Imidazol-5-yl)propan-2-amine dihydrobromide
  • 分子量
    287.00
  • 化学结构
    Chemical Structure
  • 分子式
    C6H11N3.2HBr
  • CAS编号
    75614-87-8
  • PubChem识别号
    206868
  • 存放说明
    Store at Room Temperature. The product can be stored for up to 12 months.
  • 溶解度概述
    Soluble in water to 100 mM
  • 处理

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CC(CC1=CN=CN1)N.Br.Br
  • 来源

    Synthetic

  • 研究领域

文献

This product has been referenced in:
  • Francis H  et al. H3 histamine receptor-mediated activation of protein kinase Calpha inhibits the growth of cholangiocarcinoma in vitro and in vivo. Mol Cancer Res 7:1704-13 (2009). Read more (PubMed: 19825989) »
  • Francis H  et al. H3 histamine receptor agonist inhibits biliary growth of BDL rats by downregulation of the cAMP-dependent PKA/ERK1/2/ELK-1 pathway. Lab Invest 87:473-87 (2007). Read more (PubMed: 17334413) »
  • Oishi R  et al. Effects of the histamine H3-agonist (R)-alpha-methylhistamine and the antagonist thioperamide on histamine metabolism in the mouse and rat brain. J Neurochem 52:1388-92 (1989). Read more (PubMed: 2540269) »

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