QX-314 chloride (N-Ethyllidocaine chloride),Na+ channel blocker (ab120118)
Key features and details
- Na+ channel blocker
- CAS Number: 5369-03-9
- Soluble in water to 100 mM and to 50 mM in DMSO
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
QX-314 chloride (N-Ethyllidocaine chloride),Na+ channel blocker -
描述
Na+ channel blocker -
别名
- N-Ethyllidocaine chloride
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生物学描述
A membrane impermeable quaternary lidocaine derivative. Blocks voltage-sensitive Na+ channels.
Also available in simple stock solutions (ab144493) - add 1 ml of water to get an exact, ready-to-use concentration. -
CAS编号
5369-03-9 -
化学结构
性能
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化学名称
N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium chloride -
分子量
298.85 -
分子式
C16H27ClN2O -
PubChem识别号
21462 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 100 mM and to 50 mM in DMSO -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
[Cl-].O=C(Nc1c(C)cccc1C)C[N+](CC)(CC)CC -
来源
Synthetic
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研究领域
图片
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (15)
ab120118 被引用在 15 文献中.
- Biane C et al. Developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons. Elife 10:N/A (2021). PubMed: 34730085
- Weyrer C et al. Introduction of synaptotagmin 7 promotes facilitation at the climbing fiber to Purkinje cell synapse. Cell Rep 36:109719 (2021). PubMed: 34551307
- Vaden RJ et al. Parvalbumin interneurons provide spillover to newborn and mature dentate granule cells. Elife 9:N/A (2020). PubMed: 32602839
- Rudolph S et al. Cerebellum-Specific Deletion of the GABAA Receptor d Subunit Leads to Sex-Specific Disruption of Behavior. Cell Rep 33:108338 (2020). PubMed: 33147470
- Hoehne A et al. Feed-forward recruitment of electrical synapses enhances synchronous spiking in the mouse cerebellar cortex. Elife 9:N/A (2020). PubMed: 32990593