Quinacrine dihydrochloride (ab120749)

概述

  • 产品名称
    Quinacrine dihydrochloride
  • 描述
    Non-selective phospholipase A2 inhibitor
  • 别名
    • Atebrine
    • Mepacrine
  • 生物学描述
    Non-selective phospholipase A2 inhibitor (PLA2). IC50 = 200 μM for bovine brain cPLA2. Neuroprotective properties. Centrally active upon intraperitoneal administration.
  • 纯度
    > 98%
  • 常规说明

    This product is reported to be light sensitive

性能

  • 化学名称
    N4-(6-Chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-1,4-pentanediamine dihydrochloride
  • 分子量
    472.88
  • 化学结构
    Chemical Structure
  • 分子式
    C23H30ClN3O.2HCl
  • CAS编号
    69-05-6
  • 存放说明
    Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解度概述
    Soluble in water to 100 mM (with warming)
  • 处理

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • 来源

    Synthetic

  • 研究领域

文献

This product has been referenced in:
  • Ong WY  et al. Quinacrine abolishes increases in cytoplasmic phospholipase A2 mRNA levels in the rat hippocampus after kainate-induced neuronal injury. Exp Brain Res 148:521-4 (2003). Read more (PubMed: 12582837) »
  • Lu XR  et al. Differential effects of calcium-dependent and calcium-independent phospholipase A(2) inhibitors on kainate-induced neuronal injury in rat hippocampal slices. Free Radic Biol Med 30:1263-73 (2001). Read more (PubMed: 11368924) »

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