Quercetin,Antioxidative flavonoid (ab120247)
Key features and details
- Antioxidative flavonoid
- CAS Number: 6151-25-3
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
-
产品名称
Quercetin,Antioxidative flavonoid -
描述
Antioxidative flavonoid -
生物学描述
Antioxidative flavonoid. Anticancer, antithrombotic and anti-inflammatory agent. Actions include inhibition of mitochondrial ATPase, phosphodiesterases, PI3-kinase and PIP kinase activity.
-
CAS编号
6151-25-3 -
化学结构
性能
-
化学名称
2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one -
分子量
302.24 -
分子式
C15H10O7 -
PubChem识别号
5280343 -
存放说明
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
Oc1ccc(cc1O)C=3Oc2cc(O)cc(O)c2C(=O)C=3O -
来源
Synthetic
-
研究领域
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab120247于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
Functional Studies |
Use at an assay dependent concentration.
|
说明 |
---|
Functional Studies
Use at an assay dependent concentration. |
图片
-
2D chemical structure image of ab120247, Quercetin, Antioxidative flavonoid
-
ab13847 staining active caspase 3 in A549 cells treated with quercetin (ab120247), by ICC/IF. Increase in active caspase 3 expression correlates with increased concentration of quercetin, as described in literature.
The cells were incubated at 37°C for 6h in media containing different concentrations of ab120247 (quercetin) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab13847 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab968999) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (2)
ab120247 被引用在 2 文献中.
- Lin YJ et al. Network analysis and mechanisms of action of Chinese herb-related natural compounds in lung cancer cells. Phytomedicine 58:152893 (2019). PubMed: 30901663
- Ishida K et al. Inhibition of PI3K suppresses propagation of drug-tolerant cancer cell subpopulations enriched by 5-fluorouracil. Sci Rep 7:2262 (2017). PubMed: 28536445