概述

  • 产品名称
  • 描述
    山羊多克隆抗体to QKI
  • 特异性
    ab77176 is expected to recognise all reported isoforms of QKI.
  • 经测试应用
    适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Rat, Dog, Human, Pig, Xenopus laevis, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to Human QKI aa 6-17 (N terminal). NP_006766.1; NP_996735.1; NP_996736.1; NP_996737.1
    Sequence:

    ETKEKPKPTPDY-C

  • 阳性对照
    • Mouse brain lysate.

性能

应用

Our Abpromise guarantee covers the use of ab77176 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 38 kDa.
ELISA 1/64000.

Peptide ELISA

靶标

  • 功能
    RNA-binding protein that plays a central role in myelinization (PubMed:16641098). Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Regulates target mRNA stability (PubMed:23630077). In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098). Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor.
  • 组织特异性
    Expressed in the frontal cortex of brain. Down-regulated in the brain of schizophrenic patients.
  • 序列相似性
    Contains 1 KH domain.
  • 结构域
    The KH domain and the Qua2 region are involved in RNA binding.
  • 翻译后修饰
    Methylated by PRMT1.
    Tyrosine phosphorylated at its C-terminus, probably by FYN. Phosphorylation leads to decreased mRNA-binding affinity, affecting transport and/or stabilization of MBP mRNA.
  • 细胞定位
    Nucleus. Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DKFZp586I0923 antibody
    • HKQ antibody
    • Homolog of mouse quaking QKI KH domain RNA binding protein antibody
    • Hqk antibody
    • HQK1 antibody
    • HqkI antibody
    • OTTHUMP00000017581 antibody
    • OTTHUMP00000017582 antibody
    • OTTHUMP00000017583 antibody
    • Protein quaking antibody
    • QK antibody
    • QK1 antibody
    • QK3 antibody
    • QKI antibody
    • QKI_HUMAN antibody
    • QKI1 antibody
    • Quaking homolog antibody
    • Quaking homolog KH domain RNA binding antibody
    • Quaking homolog KH domain RNA binding mouse antibody
    • Quaking isoform 1 antibody
    • Quaking protein antibody
    • RNA binding protein HQK antibody
    see all

Anti-QKI antibody 图像

  • Anti-QKI antibody (ab77176) at 0.3 µg/ml + mouse brain lysate in RIPA buffer at 35 µg

    Predicted band size : 38 kDa
    Observed band size : 38 kDa
    Primary incubation was 1 hour. Detected by chemiluminescence.

实验方案

Anti-QKI antibody (ab77176)参考文献

ab77176 has not yet been referenced specifically in any publications.

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