概述

  • 产品名称Anti-QK1抗体
    参阅全部 QK1 一抗
  • 描述
    山羊多克隆抗体to QK1
  • 特异性ab77176 is expected to recognise all reported isoforms of QK1.
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Rat, Dog, Human, Pig, Xenopus laevis, Zebrafish
  • 免疫原

    Synthetic peptide:

    ETKEKPKPTPDY-C

    , corresponding to N terminal amino acids 6-17 of Human QK1 (NP_006766.1; NP_996735.1; NP_996736.1; NP_996737.1)

  • 阳性对照
    • Mouse brain lysate.

性能

应用

Our Abpromise guarantee covers the use of ab77176 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明Peptide ELISA: Antibody detection limit dilution 1/64000.
    WB: Use at a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 38 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能RNA-binding protein that plays a central role in myelinization (PubMed:16641098). Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Regulates target mRNA stability (PubMed:23630077). In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098). Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor.
    • 组织特异性Expressed in the frontal cortex of brain. Down-regulated in the brain of schizophrenic patients.
    • 序列相似性Contains 1 KH domain.
    • 结构域The KH domain and the Qua2 region are involved in RNA binding.
    • 翻译后修饰Methylated by PRMT1.
      Tyrosine phosphorylated at its C-terminus, probably by FYN. Phosphorylation leads to decreased mRNA-binding affinity, affecting transport and/or stabilization of MBP mRNA.
    • 细胞定位Nucleus. Cytoplasm.
    • Information by UniProt
    • 数据库链接
    • 别名
      • DKFZp586I0923 antibody
      • HKQ antibody
      • Homolog of mouse quaking QKI KH domain RNA binding protein antibody
      • Hqk antibody
      • HQK1 antibody
      • HqkI antibody
      • OTTHUMP00000017581 antibody
      • OTTHUMP00000017582 antibody
      • OTTHUMP00000017583 antibody
      • Protein quaking antibody
      • QK antibody
      • QK1 antibody
      • QK3 antibody
      • QKI antibody
      • QKI_HUMAN antibody
      • QKI1 antibody
      • Quaking homolog antibody
      • Quaking homolog KH domain RNA binding antibody
      • Quaking homolog KH domain RNA binding mouse antibody
      • Quaking isoform 1 antibody
      • Quaking protein antibody
      • RNA binding protein HQK antibody
      see all

    Anti-QK1 antibody 图像

    • Anti-QK1 antibody (ab77176) at 0.3 µg/ml + mouse brain lysate in RIPA buffer at 35 µg

      Predicted band size : 38 kDa
      Observed band size : 38 kDa

    Anti-QK1 antibody (ab77176)参考文献

    ab77176 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"