Pumilio 2肽(141-155) (ab45710)

概述

  • 产品名称
    Pumilio 2肽(141-155)

描述

  • 性质
    Synthetic
  • 氨基酸序列
    • 种属
      Human
    • 序列
      C-DQNRDLKQGDDDDSK
    • 氨基酸
      141 to 155

相关产品

技术指标

Our Abpromise guarantee covers the use of ab45710 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-Pumilio 2 antibody (ab32894)

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

常规信息

  • 别名
    • FLJ36528
    • KIAA0235
    • MGC138251
    • MGC138253
    • PUM 2
    • PUM2
    • PUM2_HUMAN
    • PUMH 2
    • PUMH2
    • Pumilio (Drosphila) homolog 2
    • Pumilio homolog 2
    • Pumilio homolog 2 (Drosophila)
    • Pumilio-2
    • Pumilio2
    • PUML2
    see all
  • 功能
    Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts.
  • 组织特异性
    Expressed in male germ cells of adult testis (at protein level). Highly expressed in testis and ovary. Predominantly expressed in stem cells and germ cells. Expressed at lower level in brain, heart, kidney, liver, muscle, placenta, intestine and stomach Expressed in cerebellum, corpus callosum, caudate nucleus, hippocampus, medulla oblongata and putamen. Expressed in all fetal tissues tested.
  • 序列相似性
    Contains 1 PUM-HD domain.
    Contains 8 pumilio repeats.
  • 结构域
    The pumilio repeats mediate the association with RNA by packing together to form a right-handed superhelix that approximates a half doughnut. The number as well as the specific sequence of the repeats determine the specificity for target mRNAs.
  • 细胞定位
    Cytoplasm. Cytoplasmic granule. Cytoplasm > perinuclear region. The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). Colocalizes with NANOS1 and SNAPIN in the perinuclear region of germ cells.
  • Information by UniProt

文献

ab45710 has not yet been referenced specifically in any publications.

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