Anti-Pumilio 2抗体(ab57049)

概述

  • 产品名称Anti-Pumilio 2抗体
    参阅全部 Pumilio 2 一抗
  • 描述
    小鼠单克隆抗体to Pumilio 2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: DIMPSGRSRL LEDFRNNRFP NLQLRDLIGH IVEFSQDQHG SRFIQQKLER ATPAERQMVF NEILQAAYQL MTDVFGNYVI QKFFEFGSLD QKLALATR, corresponding to amino acids 701-799 of Human Pumilio 2

性能

应用

Our Abpromise guarantee covers the use of ab57049 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts.
    • 组织特异性Expressed in male germ cells of adult testis (at protein level). Highly expressed in testis and ovary. Predominantly expressed in stem cells and germ cells. Expressed at lower level in brain, heart, kidney, liver, muscle, placenta, intestine and stomach Expressed in cerebellum, corpus callosum, caudate nucleus, hippocampus, medulla oblongata and putamen. Expressed in all fetal tissues tested.
    • 序列相似性Contains 1 PUM-HD domain.
      Contains 8 pumilio repeats.
    • 结构域The pumilio repeats mediate the association with RNA by packing together to form a right-handed superhelix that approximates a half doughnut. The number as well as the specific sequence of the repeats determine the specificity for target mRNAs.
    • 细胞定位Cytoplasm. Cytoplasmic granule. Cytoplasm > perinuclear region. The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). Colocalizes with NANOS1 and SNAPIN in the perinuclear region of germ cells.
    • Information by UniProt
    • 数据库链接
    • 别名
      • FLJ36528 antibody
      • KIAA0235 antibody
      • MGC138251 antibody
      • MGC138253 antibody
      • PUM 2 antibody
      • PUM2 antibody
      • PUM2_HUMAN antibody
      • PUMH 2 antibody
      • PUMH2 antibody
      • Pumilio (Drosphila) homolog 2 antibody
      • Pumilio homolog 2 (Drosophila) antibody
      • Pumilio homolog 2 antibody
      • Pumilio-2 antibody
      • Pumilio2 antibody
      • PUML2 antibody
      see all

    Anti-Pumilio 2 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab57049 Pumilio 2 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    Anti-Pumilio 2 antibody (ab57049)参考文献

    ab57049 has not yet been referenced specifically in any publications.

    Product Wall

    Merci de nous avoir contactés. Nous serons ravis de vous envoyer un code de test pour des anticorps anti-RPS23, anti-pumilio2 et anti-RRM2. Avant l'édition de ces codes, je vous invite à consulter les listes des six anti-pumilio2 et des quatre anti-RRM...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"