Anti-PTS (phospho S19)抗体[EPR1517(2)] (ab109462)

概述

• 产品名称Anti-PTS (phospho S19)抗体[EPR1517(2)]
  参阅全部 PTS 一抗
• 描述
  兔单克隆抗体[EPR1517(2)] to PTS (phospho S19)
• 特异性ab109462 only detects PTS phosphorylated at Serine 19.
• 经测试应用适用于: WB, IP, IHC-P, ICC/IFmore details
  不适用于: Flow Cyt
• 种属反应性
  与反应: Human
  
• 免疫原

  A phospho specific peptide corresponding to residues surrounding Serine 19 of Human PTS.

• 阳性对照
  • HUVEC cell lysates; Human brain tissue; HeLa cells
• 常规说明

  This product is a recombinant rabbit monoclonal antibody.

  Produced using Abcam’s RabMAb^® technology. RabMAb^® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

  Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

性能

• 形式Liquid
• 存放说明Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
• 存储溶液PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• 纯度Tissue culture supernatant
• 克隆单克隆
• 克隆编号EPR1517(2)
• 同种型IgG
• 研究领域
  • Neuroscience
  • Neurotransmitter
  • Biogenic Amines
  • Dopamine

  • Neuroscience
  • Neurotransmitter
  • Biogenic Amines
  • Serotonin / 5HT

  • Signal Transduction
  • Metabolism
  • Amino Acids

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Amino acid metabolism

  • Metabolism
  • Types of disease
  • Cancer

应用

靶标

• 功能Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.
• 通路Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3.
• 疾病相关Defects in PTS are the cause of BH4-deficient hyperphenylalaninemia type A (HPABH4A) [MIM:261640]; also called 6-pyruvoyl-tetrahydropterin synthase deficiency (PTS deficiency) or hyperphenylalaninemia tetrahydrobiopterin-deficient due to PTS deficiency. HPABH4A is an autosomal recessive disorder characterized by depletion of the neurotransmitters dopamine and serotonin, and clinically by severe neurological symptoms unresponsive to the classic phenylalanine-low diet.
• 序列相似性Belongs to the PTPS family.
• 翻译后修饰Phosphorylation of Ser-19 is required for maximal enzyme activity.

• Target information above from: UniProt accession Q03393 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 5805 Human
  • GenBank: NP_000308.1 Human
  • Omim: 612719 Human
  • SwissProt: Q03393 Human
  • Unigene: 503860 Human
• 别名
  • 6 pyruvoyl tetrahydrobiopterin synthase antibody
  • 6 pyruvoyl tetrahydropterin synthase antibody
  • 6 pyruvoyltetrahydropterin synthase antibody

  • 6-pyruvoyl tetrahydrobiopterin synthase antibody
  • EC 4.2.3.12 antibody
  • FLJ97081 antibody
  • OTTHUMP00000235385 antibody
  • PTP synthase antibody
  • PTPS antibody
  • PTPS_HUMAN antibody
  • PTS antibody

  see all