Anti-PTS抗体[AT2B2] (ab106636)

概述

  • 产品名称
    Anti-PTS抗体[AT2B2]
    参阅全部 PTS 一抗
  • 描述
    小鼠单克隆抗体[AT2B2] to PTS
  • 经测试应用
    适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Recombinant full length protein, corresponding to amino acids 1-145 of Human PTS purified from E. coli (NP_000308).

  • 阳性对照
    • Mouse Kidney lysates

性能

应用

Our Abpromise guarantee covers the use of ab106636 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/250 - 1/1000. Predicted molecular weight: 16 kDa.
ELISA Use at an assay dependent dilution.

靶标

  • 功能
    Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.
  • 通路
    Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3.
  • 疾病相关
    Defects in PTS are the cause of BH4-deficient hyperphenylalaninemia type A (HPABH4A) [MIM:261640]; also called 6-pyruvoyl-tetrahydropterin synthase deficiency (PTS deficiency) or hyperphenylalaninemia tetrahydrobiopterin-deficient due to PTS deficiency. HPABH4A is an autosomal recessive disorder characterized by depletion of the neurotransmitters dopamine and serotonin, and clinically by severe neurological symptoms unresponsive to the classic phenylalanine-low diet.
  • 序列相似性
    Belongs to the PTPS family.
  • 翻译后修饰
    Phosphorylation of Ser-19 is required for maximal enzyme activity.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 6 pyruvoyl tetrahydrobiopterin synthase antibody
    • 6 pyruvoyl tetrahydropterin synthase antibody
    • 6 pyruvoyltetrahydropterin synthase antibody
    • 6-pyruvoyl tetrahydrobiopterin synthase antibody
    • EC 4.2.3.12 antibody
    • FLJ97081 antibody
    • OTTHUMP00000235385 antibody
    • PTP synthase antibody
    • PTPS antibody
    • PTPS_HUMAN antibody
    • PTS antibody
    see all

图片

  • All lanes : Anti-PTS antibody [AT2B2] (ab106636) at 1/500 dilution

    Lane 1 : Mouse kidney lysate at 40 µg
    Lane 2 : Recombinant protein at 1 µg
    Lane 3 : Recombinant protein at 0.5 µg

    Secondary
    goat anti-mouse secondary antibody conjugated to HRP
    Developed using the ECL technique

    Predicted band size : 16 kDa

实验方案

文献

ab106636 has not yet been referenced specifically in any publications.

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