Anti-PTPRB抗体[122.2] (ab31654)

概述

  • 产品名称
    Anti-PTPRB抗体[122.2]
  • 描述
    小鼠单克隆抗体[122.2] to PTPRB
  • 特异性
    This antibody is specific for Receptor Tyrosine Phosphatase Beta (phosphacan).
  • 经测试应用
    适用于: WB, ICC/IF, ICC, IPmore details
  • 种属反应性
    与反应: Rat
  • 免疫原

    Embryonic rat brain proteoglycans.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • 存储溶液
    Preservative: None
    Constituents: PBS
  • Concentration information loading...
  • 纯化说明
    Concentrated antibody. This antibody was grown in protein free medium, then concentrated snd dialysed against PBS.
  • 克隆
    单克隆
  • 克隆编号
    122.2
  • 同种型
    IgM
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab31654 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/2500. Predicted molecular weight: 224 kDa.
ICC/IF Use at an assay dependent dilution.
ICC Use at an assay dependent dilution.
IP Use at an assay dependent dilution.

靶标

  • 功能
    Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin.
  • 序列相似性
    Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.
    Contains 17 fibronectin type-III domains.
    Contains 1 tyrosine-protein phosphatase domain.
  • 细胞定位
    Membrane.
  • Information by UniProt
  • 别名
    • HPTP BETA antibody
    • HPTPB antibody
    • Phosphacan receptor type B antibody
    • Protein tyrosine phosphatase receptor type B antibody
    • Protein-tyrosine phosphatase beta antibody
    • PTPB antibody
    • Ptprb antibody
    • PTPRB_HUMAN antibody
    • R PTP BETA antibody
    • R-PTP-beta antibody
    • Receptor-type tyrosine-protein phosphatase beta antibody
    • RPTPB antibody
    • Vascular endothelial protein tyrosine phosphatase antibody
    • VE-PTP antibody
    see all

文献

ab31654 has not yet been referenced specifically in any publications.

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