概述

  • 产品名称Anti-PTPN13抗体[AC21]
    参阅全部 PTPN13 一抗
  • 描述
    小鼠单克隆抗体[AC21] to PTPN13
  • 特异性Human PTPN13 protein.
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Prokaryotic recombinant fusion protein corresponding to N terminal amino acids 239-342 of Human PTPN13 (Fas-associated phosphatase 1).

  • 阳性对照
    • Tonsil and normal human thyroid.
  • 常规说明Staining pattern is mainly cytoplasmic with occasional nuclear staining observed.

性能

应用

Our Abpromise guarantee covers the use of ab49446 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/40 - 1/80. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. Incubate with primary antibody for 60 minutes at 25°C.

靶标

  • 相关性PTPN13 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. This PTP was found to interact with, and dephosphorylate Fas receptor, as well as I-kappa-B-alpha through the PDZ domains, which suggested its role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathway.
  • 细胞定位Cytoplasmic
  • 数据库链接
  • 别名
    • APO1/CD95 (Fas) associated phosphatase antibody
    • DKFZp686J1497 antibody
    • FAP 1 antibody
    • FAP1 antibody
    • Fas associated phosphatase 1 antibody
    • Fas associated protein tyrosine phosphatase 1 antibody
    • HGNC:9646 antibody
    • hPTPE1 antibody
    • Phosphatase rip antibody
    • PNP 1 antibody
    • PNP1 antibody
    • Protein tyrosine phosphatase 1 Fas associated antibody
    • protein tyrosine phosphatase 1E antibody
    • Protein tyrosine phosphatase non receptor type 13 antibody
    • Protein tyrosine phosphatase nonreceptor type 13 antibody
    • Protein tyrosine phosphatase PTPL1 antibody
    • protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) antibody
    • PTP BAS antibody
    • PTP BL antibody
    • PTP E1 antibody
    • PTP1E antibody
    • PTPL 1 antibody
    • PTPL1 antibody
    • PTPLE antibody
    • PTPN 13 antibody
    • PTPN13 antibody
    • Tyrosine protein phosphatase non receptor type 13 antibody
    see all

Anti-PTPN13 antibody [AC21] 图像

  • Immunohistochemical staining (Paraffin section) for PTPN13 (Fas-associated phosphatase 1) using ab49446 with normal Human thyroid as positive control. Note intense cytoplasmic staining of thyroid epithelial cells.

Anti-PTPN13 antibody [AC21] (ab49446)参考文献

This product has been referenced in:
  • Glondu-Lassis M  et al. PTPL1/PTPN13 regulates breast cancer cell aggressiveness through direct inactivation of Src kinase. Cancer Res 70:5116-26 (2010). IHC-P ; Human . Read more (PubMed: 20501847) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab49446.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"