概述

  • 产品名称Anti-PTP4A3抗体[111AT714]
    参阅全部 PTP4A3 一抗
  • 描述
    小鼠单克隆抗体[111AT714] to PTP4A3
  • 经测试应用适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Recombinant full length protein corresponding to Mouse PTP4A3.

  • 阳性对照
    • WB: 293 cells transfected with PTP4A3.

性能

应用

Our Abpromise guarantee covers the use of ab38673 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 20 kDa.
ICC/IF Use at an assay dependent concentration. PubMed: 19586538

靶标

  • 功能Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
  • 组织特异性Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis.
  • 序列相似性Belongs to the protein-tyrosine phosphatase family.
    Contains 1 tyrosine-protein phosphatase domain.
  • 翻译后修饰Farnesylated. Farnesylation is required for membrane targeting.
  • 细胞定位Cell membrane. Early endosome.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Potentially prenylated protein tyrosine phosphatase antibody
    • PRL 3 antibody
    • PRL R antibody
    • PRL-3 antibody
    • PRL-R antibody
    • PRL3 antibody
    • PRLR antibody
    • Protein tyrosine phosphatase 4a3 antibody
    • Protein tyrosine phosphatase type IVA 3 antibody
    • Protein-tyrosine phosphatase 4a3 antibody
    • Protein-tyrosine phosphatase of regenerating liver 3 antibody
    • PTP 4A3 antibody
    • PTP4A3 antibody
    • TP4A3_HUMAN antibody
    see all

Anti-PTP4A3 antibody [111AT714] 图像

  • Anti-PTP4A3 antibody [111AT714] (ab38673) at 1/100 dilution + 293 cells transfected with PTP4A3 at 35 µg

    Predicted band size : 20 kDa
    Observed band size : 20 kDa

Anti-PTP4A3 antibody [111AT714] (ab38673)参考文献

This product has been referenced in:
  • Molleví DG  et al. PRL-3 overexpression in epithelial cells is induced by surrounding stromal fibroblasts. Mol Cancer 8:46 (2009). ICC/IF ; Human . Read more (PubMed: 19586538) »

See 1 Publication for this product

Product Wall

Application Western blot
Sample Human Recombinant protein (COS7 extract expressing both HA-tagged and no-tag)
Loading amount 20 µg
Specification COS7 extract expressing both HA-tagged and no-tag
Gel Running Conditions Reduced Denaturing (15 % SDS-PAG)
Blocking step Blocking One as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 100%
Username

Abcam user community

Verified customer

提交于 Apr 17 2009

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"