RabMAb

Anti-PTP1B (phospho S50)抗体[EP1838Y] (ab62320)

概述

  • 产品名称Anti-PTP1B (phospho S50)抗体[EP1838Y]
    参阅全部 PTP1B 一抗
  • 描述
    兔单克隆抗体[EP1838Y] to PTP1B (phospho S50)
  • 特异性This antibody detects PTP1B when phosphorylated at Serine 50.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    A phospho specific peptide corresponding to residues surround Serine 50 of human PTP1B.

  • 阳性对照
    • Hela cell lysate.
  • 常规说明

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab62320 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/2500 - 1/5000. Detects a band of approximately 50 kDa (predicted molecular weight: 50 kDa).

靶标

  • 功能May play an important role in CKII- and p60c-src-induced signal transduction cascades.
  • 序列相似性Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.
    Contains 1 tyrosine-protein phosphatase domain.
  • 翻译后修饰Oxidized on Cys-215; the Cys-SOH formed in response to redox signaling reacts with the alpha-amido of the following residue to form a 4-amino-3-isothiazolidinone serine cross-link, triggering a conformational change that inhibits substrate binding and activity. The active site can be restored by reduction.
  • 细胞定位Endoplasmic reticulum membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • PTP1B antibody
    • Non receptor tyrosine phosphatase 1 antibody
    • Protein phosphotyrosylphosphatase 1B antibody
    • Protein tyrosine phosphatase 1B antibody
    • Protein tyrosine phosphatase non receptor type 1 antibody
    • Protein tyrosine phosphatase placental antibody
    • Protein-tyrosine phosphatase 1B antibody
    • PTN1_HUMAN antibody
    • PTP 1B antibody
    • PTP-1B antibody
    • PTPN 1 antibody
    • PTPN1 antibody
    • Tyrosine protein phosphatase non receptor type 1 antibody
    • Tyrosine-protein phosphatase non-receptor type 1 antibody
    see all

Anti-PTP1B (phospho S50) antibody [EP1838Y] 图像

  • All lanes : Anti-PTP1B (phospho S50) antibody [EP1838Y] (ab62320) at 1/5000 dilution

    Lane 1 : Hela cell lysate - untreated cells
    Lane 2 : Hela cell lysate - treated with Calyculin A

    Lysates/proteins at 10 µg per lane.

    Secondary
    goat anti-rabbit HRP at 1/2000 dilution

    Predicted band size : 50 kDa
    Observed band size : 50 kDa

Anti-PTP1B (phospho S50) antibody [EP1838Y] (ab62320)参考文献

ab62320 has not yet been referenced specifically in any publications.

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