Anti-PTP epsilon抗体(ab123345)


  • 产品名称
    Anti-PTP epsilon抗体
    参阅全部 PTP epsilon 一抗
  • 描述
    兔多克隆抗体to PTP epsilon
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 133-163 of Human PTP epsilon (NP_569119.1, NP_006495.1).

  • 阳性对照
    • CEM cell line lysates.



Our Abpromise guarantee covers the use of ab123345 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 71 kDa.


  • 功能
    Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function.
    Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake.
    Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+).
  • 组织特异性
    Expressed in giant cell tumor (osteoclastoma rich in multinucleated osteoclastic cells).
  • 序列相似性
    Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
    Contains 2 tyrosine-protein phosphatase domains.
  • 结构域
    The tyrosine-protein phosphatase 2 domain (D2) mediates dimerization. The extreme N- and C- termini of the D2 domain act to inhibit dimerization and removal of these sequences increases dimerization and inhibits enzyme activity.
  • 翻译后修饰
    A catalytically active cytoplasmic form (p65) is produced by proteolytic cleavage of either isoform 1, isoform 2 or isoform 3.
    Isoform 1 and isoform 2 are phosphorylated on tyrosine residues by tyrosine kinase Neu.
    Isoform 1 is glycosylated.
  • 细胞定位
    Cytoplasm; Cell membrane and Cytoplasm. Predominantly cytoplasmic. A small fraction is also associated with nucleus and membrane. Insulin induces translocation to the membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DKFZp313F1310 antibody
    • FLJ57799 antibody
    • FLJ58245 antibody
    • HPTPE antibody
    • Protein tyrosine phosphatase epsilon antibody
    • Protein tyrosine phosphatase receptor type E antibody
    • Protein tyrosine phosphatase receptor type epsilon antibody
    • Protein tyrosine phosphatase receptor type epsilon polypeptide antibody
    • Protein-tyrosine phosphatase epsilon antibody
    • PTPE antibody
    • Ptpre antibody
    • PTPRE_HUMAN antibody
    • R PTP Epsilon antibody
    • R-PTP-epsilon antibody
    • Receptor-type tyrosine-protein phosphatase epsilon antibody
    see all

Anti-PTP epsilon antibody 图像

  • Anti-PTP epsilon antibody (ab123345) at 1/100 dilution + CEM cell line lysates at 35 µg

    Predicted band size : 71 kDa


Anti-PTP epsilon antibody (ab123345)参考文献

ab123345 has not yet been referenced specifically in any publications.

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