• 产品名称Anti-PTIP抗体
    参阅全部 PTIP 一抗
  • 描述
    小鼠单克隆抗体to PTIP
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 868-976 of Human PTIP



Our Abpromise guarantee covers the use of ab56934 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. Plays a role in early development. In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs). Its localization to DNA damage foci requires RNF8 and UBE2N. Recruits TP53BP1 to DNA damage foci and, at least in particular repair processes, effective DNA damage response appears to require the association with TP53BP1 phosphorylated by ATM at 'Ser-25'. Together with TP53BP1 regulates ATM association. Recruits PA1 to sites of DNA damage and the PA1:PAXIP1 complex is required for cell survival in response to DNA damage; the function is probbaly independent of MLL-containing histone methyltransferase (HMT) complexes. Promotes ubiquitination of PCNA following UV irradiation and may regulate recruitment of polymerase eta and RAD51 to chromatin after DNA damage. Proposed to be involved in transcriptional regulation by linking MLL-containing histone methyltransferase (HMT) complexes to gene promoters by interacting with promoter-bound transcription factors such as PAX2. Associates with gene promoters that are known to be regulated by MLL2. During immunoglobulin class switching in activated B cells is involved in trimethylation of histone H3 at 'Lys-4' and in transcription initiation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus; this function appears to involve the recruitment of MLL-containing HMT complexes.
    • 序列相似性Contains 6 BRCT domains.
    • 结构域The BRCT 5 and 6 domains function as a single module and are necessary and sufficient for in vitro phospho-specific binding (substrates phosphorylated by the kinases ataxia telangiectasia-mutated (ATM), ataxia telangiectasia and RAD3-related (ATR) in response to gamma irradiation). In contrast, in vivo two pairs of BRCT domains (3-6) bind to phosphorylated TP53BP1 much more efficiently.
    • 细胞定位Nucleus matrix. Localizes to DNA damage foci upon ionizing radiation.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CAGF 28 antibody
      • CAGF 29 antibody
      • CAGF28 antibody
      • CAGF29 antibody
      • FLJ41049 antibody
      • PACIP 1 antibody
      • PACIP1 antibody
      • PAX interacting (with transcription activation domain) protein 1 antibody
      • PAX interacting protein 1 antibody
      • PAX transactivation activation domain-interacting protein antibody
      • PAX transcription activation domain interacting protein 1 like antibody
      • PAX-interacting protein 1 antibody
      • PAXI1_HUMAN antibody
      • PAXIP 1 antibody
      • PAXIP 1L antibody
      • paxip1 antibody
      • PAXIP1 protein antibody
      • PAXIP1L antibody
      • Protein encoded by CAG trinucleotide repeats antibody
      • PTIP antibody
      • TNRC 2 antibody
      • TNRC2 antibody
      see all

    Anti-PTIP antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab56934 PTIP antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa

    Anti-PTIP antibody (ab56934)参考文献

    ab56934 has not yet been referenced specifically in any publications.

    Product Wall

    Thank you for confirming these details and for your cooperation.

    I am sorry this product did not perform as stated on the datasheet and for the inconvenience this has caused. As requested, I have issued a free of charge replacement with ab70...

    Read More

    Thank you for taking time to provide me with those details. I am sorry to hear that this antibodyhas not been providing the expectedresults.

    The details provided will enable us to investigate this case and will provide us with vital informat...

    Read More

    Thank you for contacting us.

    I am sorry to hear you are experiencing difficulties with the anti-PTIP antibody(ab56934). We take product complaints very seriously, and investigate every product that we feel may not be performing correctly. Read More