概述

  • 产品名称
  • 描述
    兔多克隆抗体to PTHLH
  • 特异性
    Polypeptide % Cross Reactivity: PTHrp(1-35) 100 PTH (1-34) (Human) >1 PTH (1-84) (Human) >0.5 PTH (1-34) (Bovine) >1 Atrial Natriuretic Polypeptide (Human) 0 ACTH (Human, 1-39) 0 Calcitonin (Human) 0 Epidermal growth factor (Human) 0 Somatostatin 28 0 Transforming Growth Factor-alpha (Human) 0 VIP 0
  • 经测试应用
    适用于: WBmore details
  • 种属反应性

    预测可用于: Mouse, Rat, Sheep, Rabbit, Horse, Cow, Cat, Dog, Human, Pig, Deer
  • 免疫原

    Synthetic peptide: AVSEHQLLHD KGKSIQDLRR RFFLHHLIAE IHTAE, corresponding to amino acids 1-35 of PTHLH

性能

应用

Our Abpromise guarantee covers the use of ab40642 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明
    WB: Use at an assay dependent dilution. Predicted molecular weight: 20 kDa.

    With this antibody, we have found that blocking with 5% goat or donkey serum significantly reduces background as compared to BSA or milk.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能
      Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.
      Osteostatin is a potent inhibitor of osteoclastic bone resorption.
    • 组织特异性
      Ubiquitous. Also expressed in the mammary gland.
    • 疾病相关
      Brachydactyly E2
    • 序列相似性
      Belongs to the parathyroid hormone family.
    • 翻译后修饰
      There are 3 principal secretory forms, called PTHrP[1-36], PTHrP[38-94], and osteostatin (PTHrP[107-139]) arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions.
    • 细胞定位
      Cytoplasm. Nucleus. Secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • HHM antibody
      • MGC14611 antibody
      • Osteostatin antibody
      • Parathyroid hormon like hormone isoform 2 preproprotein antibody
      • Parathyroid hormone like hormone antibody
      • Parathyroid hormone like hormone isoform 1 preproprotein antibody
      • Parathyroid hormone like protein antibody
      • Parathyroid hormone like related protein antibody
      • Parathyroid hormone related protein antibody
      • Parathyroid hormone-like protein antibody
      • Parathyroid like protein antibody
      • PLP antibody
      • PTH related protein antibody
      • PTH-rP antibody
      • PTHLH antibody
      • PTHR antibody
      • PTHR_HUMAN antibody
      • PTHrP antibody
      • PTHrP[107-139] antibody
      see all

    实验方案

    文献

    ab40642 has not yet been referenced specifically in any publications.

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    There are currently no Customer reviews or Questions for ab40642.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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