Anti-PTHLH抗体(ab14199)

概述

• 产品名称
  Anti-PTHLH抗体
  参阅全部 PTHLH 一抗
• 描述
  兔多克隆抗体to PTHLH
• 经测试应用
  适用于: RIAmore details
• 种属反应性
  与反应: Human
  
• 免疫原

  Synthetic peptide:

  AVSEHQLLHDKGKSIQDLRRRFFLHHLIA

  conjugated to KLH, corresponding to amino acids 1-30 of Human PTHLH.

  Run BLAST with Run BLAST with

性能

• 形式
  Liquid
• 存放说明
  Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• 纯度
  Whole antiserum
• 克隆
  多克隆
• 同种型
  IgG
• 研究领域
  • Signal Transduction
  • Growth Factors/Hormones
  • Hormones

  • Cell Biology
  • Cell Cycle
  • Cell differentiation

  • Stem Cells
  • Mesenchymal Stem Cells
  • Surface Molecules

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • Recombinant Human PTHLH protein (ab50228)

应用

靶标

• 功能
  Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.
  Osteostatin is a potent inhibitor of osteoclastic bone resorption.
• 组织特异性
  Ubiquitous. Also expressed in the mammary gland.
• 疾病相关
  Brachydactyly E2
• 序列相似性
  Belongs to the parathyroid hormone family.
• 翻译后修饰
  There are 3 principal secretory forms, called PTHrP[1-36], PTHrP[38-94], and osteostatin (PTHrP[107-139]) arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions.
• 细胞定位
  Cytoplasm. Nucleus. Secreted.

• Target information above from: UniProt accession P12272 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 5744 Human
  • Omim: 168470 Human
  • SwissProt: P12272 Human
  • Unigene: 591159 Human
• 别名
  • HHM antibody
  • MGC14611 antibody
  • Osteostatin antibody

  • Parathyroid hormon like hormone isoform 2 preproprotein antibody
  • Parathyroid hormone like hormone antibody
  • Parathyroid hormone like hormone isoform 1 preproprotein antibody
  • Parathyroid hormone like protein antibody
  • Parathyroid hormone like related protein antibody
  • Parathyroid hormone related protein antibody
  • Parathyroid hormone-like protein antibody
  • Parathyroid like protein antibody
  • PLP antibody
  • PTH related protein antibody
  • PTH-rP antibody
  • PTHLH antibody
  • PTHR antibody
  • PTHR_HUMAN antibody
  • PTHrP antibody
  • PTHrP[107-139] antibody

  see all