概述

性能

应用

Our Abpromise guarantee covers the use of ab14199 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
RIA 1/2000.

靶标

  • 功能
    Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.
    Osteostatin is a potent inhibitor of osteoclastic bone resorption.
  • 组织特异性
    Ubiquitous. Also expressed in the mammary gland.
  • 疾病相关
    Brachydactyly E2
  • 序列相似性
    Belongs to the parathyroid hormone family.
  • 翻译后修饰
    There are 3 principal secretory forms, called PTHrP[1-36], PTHrP[38-94], and osteostatin (PTHrP[107-139]) arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions.
  • 细胞定位
    Cytoplasm. Nucleus. Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • HHM antibody
    • MGC14611 antibody
    • Osteostatin antibody
    • Parathyroid hormon like hormone isoform 2 preproprotein antibody
    • Parathyroid hormone like hormone antibody
    • Parathyroid hormone like hormone isoform 1 preproprotein antibody
    • Parathyroid hormone like protein antibody
    • Parathyroid hormone like related protein antibody
    • Parathyroid hormone related protein antibody
    • Parathyroid hormone-like protein antibody
    • Parathyroid like protein antibody
    • PLP antibody
    • PTH related protein antibody
    • PTH-rP antibody
    • PTHLH antibody
    • PTHR antibody
    • PTHR_HUMAN antibody
    • PTHrP antibody
    • PTHrP[107-139] antibody
    see all

文献

ab14199 has not yet been referenced specifically in any publications.

客户评价及客户问答

There are currently no Customer reviews or Questions for ab14199.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

注册