Anti-PTHLH抗体(ab125700)
Key features and details
- Rabbit polyclonal to PTHLH
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-PTHLH抗体
参阅全部 PTHLH 一抗 -
描述
兔多克隆抗体to PTHLH -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat, Rabbit, Cow, Dog, Pig -
免疫原
Recombinant fragment containing a sequence corresponding to a region within amino acids 1-127 of Human PTHLH.(Uniprot: P12272)
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阳性对照
- A549 cell lysate, HepG2 whole cell lysate (ab7900) and HTC116 cell lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab125700于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/3000. Predicted molecular weight: 20 kDa.
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说明 |
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WB
1/500 - 1/3000. Predicted molecular weight: 20 kDa. |
靶标
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功能
Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.
Osteostatin is a potent inhibitor of osteoclastic bone resorption. -
组织特异性
Ubiquitous. Also expressed in the mammary gland. -
疾病相关
Brachydactyly E2 -
序列相似性
Belongs to the parathyroid hormone family. -
翻译后修饰
There are 3 principal secretory forms, called PTHrP[1-36], PTHrP[38-94], and osteostatin (PTHrP[107-139]) arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions. -
细胞定位
Cytoplasm. Nucleus. Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 286767 Cow
- Entrez Gene: 403987 Dog
- Entrez Gene: 5744 Human
- Entrez Gene: 19227 Mouse
- Entrez Gene: 396951 Pig
- Entrez Gene: 24695 Rat
- Omim: 168470 Human
- SwissProt: P58073 Cow
see all -
别名
- HHM antibody
- MGC14611 antibody
- Osteostatin antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (4)
ab125700 被引用在 4 文献中.
- Dou P et al. Downregulation of microRNA-29b by DNMT3B decelerates chondrocyte apoptosis and the progression of osteoarthritis via PTHLH/CDK4/RUNX2 axis. Aging (Albany NY) 13:7676-7690 (2020). PubMed: 33177241
- Bai M et al. miR-182-5p overexpression inhibits chondrogenesis by down-regulating PTHLH. Cell Biol Int 43:222-232 (2019). PubMed: 30095215
- Duan Z & Lu J Involvement of Aryl Hydrocarbon Receptor in L-Kynurenine-Mediated Parathyroid Hormone-Related Peptide Expression. Horm Cancer N/A:N/A (2019). PubMed: 30689168
- Cao X et al. miR-195 contributes to human osteoarthritis via targeting PTHrP. J Bone Miner Metab N/A:N/A (2018). PubMed: 30465089