概述

  • 产品名称Anti-PSME3抗体
    参阅全部 PSME3 一抗
  • 描述
    兔多克隆抗体to PSME3
  • 特异性Detects recombinant human proteasome activator 11S REG gamma subunit.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Chicken, Pig, Cynomolgus Monkey
  • 免疫原

    Synthetic peptide corresponding to Human PSME3 aa 1-14.
    Sequence:

    MASLLKVDQEVKLK


    (Peptide available as ab4950)

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab3334 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 28 kDa (predicted molecular weight: 29 kDa).Can be blocked with PSME3 peptide (ab4950).

靶标

  • 功能Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a donut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation.
  • 序列相似性Belongs to the PA28 family.
  • 结构域The C-terminal sequences affect heptamer stability and proteasome affinity.
  • 翻译后修饰Phosphorylated by MAP3K3.
  • 细胞定位Nucleus. Cytoplasm. Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 11S regulator complex gamma subunit antibody
    • 11S regulator complex subunit gamma antibody
    • Activator of multicatalytic protease subunit 3 antibody
    • Ki antibody
    • Ki antigen antibody
    • Ki nuclear autoantigen antibody
    • Ki, PA28 gamma antibody
    • PA28 gamma antibody
    • PA28g antibody
    • PA28gamma antibody
    • Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) antibody
    • Proteasome (prosome, macropain) activator subunit 3 antibody
    • Proteasome activator 28 gamma antibody
    • Proteasome activator 28 subunit gamma antibody
    • Proteasome activator complex subunit 3 antibody
    • Proteasome activator subunit 3 antibody
    • PSME3 antibody
    • PSME3_HUMAN antibody
    • REG GAMMA antibody
    • REG-gamma antibody
    see all

Anti-PSME3 antibody 图像



  • Predicted band size : 29 kDa

    Western blot detection of recombinant Human PSME3 using ab3334.

Anti-PSME3 antibody (ab3334)参考文献

ab3334 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab3334.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"