概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • AccessionP28074
    • 序列WIRVSSDNVADLHDKYS
    • 氨基酸243 to 259

相关产品

技术指标

Our Abpromise guarantee covers the use of ab4946 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • 补充说明


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human proteasome PSMB5, catalog ab3330. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

常规信息

  • 别名
    • DKFZp459C139
    • EC 3.4.25.1
    • LMPX
    • Macropain epsilon chain
    • MB1
    • MGC104214
    • MGC118075
    • MGC134464
    • Multicatalytic endopeptidase complex epsilon chain
    • Proteasome (prosome, macropain) subunit, beta type, 5
    • Proteasome beta 5 subunit
    • Proteasome catalytic subunit 3
    • Proteasome chain 6
    • Proteasome epsilon chain
    • Proteasome subunit beta type-5
    • Proteasome subunit MB1
    • Proteasome subunit X
    • Proteasome subunit, beta type, 5
    • Proteasome subunit, beta-5
    • PSB5_HUMAN
    • PSMB5
    • PSX large multifunctional protease X
    • X
    see all
  • 功能The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the chymotrypsin-like activity of the proteasome and is one of the principal target of the proteasome inhibitor bortezomib. May catalyze basal processing of intracellular antigens. Plays a role in the protection against oxidative damage throught the Nrf2-ARE pathway.
  • 序列相似性Belongs to the peptidase T1B family.
  • 细胞定位Cytoplasm. Nucleus.
  • Information by UniProt

PSMB5 peptide (ab4946)参考文献

ab4946 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"