概述

  • 产品名称
  • 描述
    兔多克隆抗体to PSMA7
  • 经测试应用
    适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Zebrafish
  • 免疫原

    Recombinant fragment corresponding to Human PSMA7 aa 10-217.
    Database link: O14818

  • 阳性对照
    • WB: 293T, A431, H1299, HeLa, HepG2, MOLT4 and Raji cell lysates IHC-P: CL15 xenograft

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab97564 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 28 kDa.
IHC-P 1/100 - 1/500.

靶标

  • 功能
    The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor regulation, cell cycle transition, viral replication and even tumor initiation and progression. Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.
  • 序列相似性
    Belongs to the peptidase T1A family.
  • 翻译后修饰
    Phosphorylation by ABL1 or ABL2 leads to an inhibition of proteasomal activity and cell cycle transition blocks.
  • 细胞定位
    Cytoplasm. Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C6 antibody
    • HSPC antibody
    • MGC3755 antibody
    • OTTHUMP00000031449 antibody
    • OTTHUMP00000031450 antibody
    • OTTHUMP00000031453 antibody
    • Proteasome (prosome macropain) subunit alpha type 7 antibody
    • Proteasome alpha 7 subunit antibody
    • Proteasome subunit alpha 4 antibody
    • Proteasome subunit alpha type 7 antibody
    • Proteasome subunit alpha type-7 antibody
    • Proteasome subunit RC6 1 antibody
    • Proteasome subunit RC6-1 antibody
    • Proteasome subunit XAPC7 antibody
    • PSA7_HUMAN antibody
    • PSMA 7 antibody
    • PSMA7 antibody
    • RC6 1 antibody
    • XAPC7 antibody
    see all

图片

  • All lanes : Anti-PSMA7 antibody (ab97564) at 1/1000 dilution

    Lane 1 : A431 whole cell lysate
    Lane 2 : H1299 whole cell lysate
    Lane 3 : HeLa whole cell lysate
    Lane 4 : HepG2 whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 28 kDa
  • ab97564, at a 1/100 dilution, staining PSMA7 in a paraffin-embedded CL15 xenograft by Immunohistochemical analysis.

文献

ab97564 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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