概述

  • 产品名称Anti-PSMA7抗体
    参阅全部 PSMA7 一抗
  • 描述
    兔多克隆抗体to PSMA7
  • 经测试应用适用于: WB, IPmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Full length protein corresponding to Human PSMA7 aa 1-248.
    Database link: O14818

  • 阳性对照
    • Mouse intestine and PSMA7 transfected 293T cell line lysate

性能

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应用

Our Abpromise guarantee covers the use of ab118350 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 28 kDa.
IP Use at an assay dependent dilution.

靶标

  • 功能The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor regulation, cell cycle transition, viral replication and even tumor initiation and progression. Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.
  • 序列相似性Belongs to the peptidase T1A family.
  • 翻译后修饰Phosphorylation by ABL1 or ABL2 leads to an inhibition of proteasomal activity and cell cycle transition blocks.
  • 细胞定位Cytoplasm. Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C6 antibody
    • HSPC antibody
    • MGC3755 antibody
    • OTTHUMP00000031449 antibody
    • OTTHUMP00000031450 antibody
    • OTTHUMP00000031453 antibody
    • Proteasome (prosome macropain) subunit alpha type 7 antibody
    • Proteasome alpha 7 subunit antibody
    • Proteasome subunit alpha 4 antibody
    • Proteasome subunit alpha type 7 antibody
    • Proteasome subunit alpha type-7 antibody
    • Proteasome subunit RC6 1 antibody
    • Proteasome subunit RC6-1 antibody
    • Proteasome subunit XAPC7 antibody
    • PSA7_HUMAN antibody
    • PSMA 7 antibody
    • PSMA7 antibody
    • RC6 1 antibody
    • XAPC7 antibody
    see all

Anti-PSMA7 antibody 图像

  • Anti-PSMA7 antibody (ab118350) at 1/1000 dilution + Mouse intestine lysate at 50 µg/ml

    Predicted band size : 28 kDa
  • All lanes : Anti-PSMA7 antibody (ab118350) at 1/1000 dilution

    Lane 1 : PSMA7 transfected 293T cell line lysate
    Lane 2 : Non-transfected lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 28 kDa
  • Immunoprecipitation of PSMA7 transfected lysate using ab118350 and Protein A Magnetic Bead, immunoblotted with an Anit-Mouse polyclonal antibody.

Anti-PSMA7 antibody (ab118350)参考文献

ab118350 has not yet been referenced specifically in any publications.

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