概述

  • 产品名称Anti-PSKH1抗体
    参阅全部 PSKH1 一抗
  • 描述
    兔多克隆抗体to PSKH1
  • 经测试应用适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Cow
  • 免疫原

    Recombinant fragment containing a sequence corresponding to a region within amino acids 1-188 of Human PSKH1 (AAH62616).

  • 阳性对照
    • WB: MOLT4 whole cell lysate; 293T, A431, H1299, HeLa S3, HepG2 and Raji cell lines ICC/IF: Hela cell

性能

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应用

Our Abpromise guarantee covers the use of ab96602 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 48 kDa.
ICC/IF 1/100 - 1/200.

靶标

  • 功能May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing.
  • 组织特异性Expressed in all tissues and cell lines tested with the highest level of abundance in testis.
  • 序列相似性Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
    Contains 1 protein kinase domain.
  • 翻译后修饰Autophosphorylated on serine residues.
    Myristoylated. Required for membrane association. Prerequisite for palmitoylation to occur.
    Palmitoylated.
  • 细胞定位Golgi apparatus. Cytoplasm > cytoskeleton > centrosome. Nucleus speckle. Endoplasmic reticulum membrane. Cell membrane. Cytoplasm. Localized in the brefeldin A-sensitive Golgi compartment, at centrosomes, in the nucleus with a somewhat speckle-like presence, membrane-associated to the endoplasmic reticulum (ER) and the plasma membrane (PM), and more diffusely in the cytoplasm. Found to concentrate in splicing factor compartments (SFCs) within the nucleus of interphase cells. The acylation-negative form may be only cytoplasmic and nuclear. Acylation seems to allow the sequestering to the intracellular membranes. Myristoylation may mediate targeting to the intracellular non-Golgi membranes and palmitoylation may mediate the targeting to the Golgi membranes. Dual acylation is required to stabilize the interaction with Golgi membranes.
  • Information by UniProt
  • 数据库链接
  • 别名
    • KPSH1_HUMAN antibody
    • Protein serine kinase H1 antibody
    • PSK H1 antibody
    • PSK-H1 antibody
    • PSKH1 antibody
    • Serine/threonine protein kinase H1 antibody
    • Serine/threonine-protein kinase H1 antibody
    see all

Anti-PSKH1 antibody 图像

  • Anti-PSKH1 antibody (ab96602) at 1/1000 dilution + MOLT4 whole cell lysate at 30 µg

    Predicted band size : 48 kDa
  • ab96602, at 1/200 dilution, staining PSKH1 in paraformaldehyde fixed HeLa cells by Immunofluorescence. Lower image is merged with DNA probe.

Anti-PSKH1 antibody (ab96602)参考文献

ab96602 has not yet been referenced specifically in any publications.

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