概述

  • 产品名称
    PSB 11 hydrochloride
  • 描述
    Potent, selective, competitive人A3 receptor antagonist
  • 别名
    • PSB11 hydrochloride
  • 生物学描述

    Potent, selective, competitive human A3 receptor antagonist (Ki values are 2.3 nM and 10 μM for human and rat A3 receptors, respectively), Antagonises human A1 and A2A receptors. Shows inverse agonist effects in the [35S]GTPγS binding assay. Shows anti-inflammatory effects.

  • 纯度
    > 99%

性能

  • 化学名称
    (R)-8-Ethyl-3,4,7,8-tetrahydro-4-methyl-2-phenyl-5H-imidazo[2,1-i]purin-5-one hydrochloride
  • 分子量
    331.80
  • 化学结构
    Chemical Structure
  • 分子式
    C16H17N5O.HCl
  • CAS编号
    453591-58-7
  • PubChem识别号
    16759152
  • 存放说明
    Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • 溶解度概述
    Soluble in DMSO to 25 mM
  • 处理

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    Cl.O=C2N(C)c3nc(nc3C1=N[C@@H](CN12)CC)c4ccccc4
  • 来源

    Synthetic

文献

This product has been referenced in:
  • Sekharan S  et al. Spectral tuning of ultraviolet cone pigments: an interhelical lock mechanism. J Am Chem Soc 135:19064-7 (2013). Read more (PubMed: 24295328) »
  • Kim SK  et al. Docking studies of agonists and antagonists suggest an activation pathway of the A3 adenosine receptor. J Mol Graph Model 25:562-77 (2006). Read more (PubMed: 16793299) »
  • Ozola V  et al. 2-Phenylimidazo[2,1-i]purin-5-ones: structure-activity relationships and characterization of potent and selective inverse agonists at Human A3 adenosine receptors. Bioorg Med Chem 11:347-56 (2003). Read more (PubMed: 12517430) »
  • Müller CE Medicinal chemistry of adenosine A3 receptor ligands. Curr Top Med Chem 3:445-62 (2003). Read more (PubMed: 12570761) »
  • Müller CE  et al. Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A(2A)- and A(3)-adenosine receptor antagonists. J Med Chem 45:3440-50 (2002). Read more (PubMed: 12139454) »
  • Gao ZG  et al. Selective allosteric enhancement of agonist binding and function at human A3 adenosine receptors by a series of imidazoquinoline derivatives. Mol Pharmacol 62:81-9 (2002). Read more (PubMed: 12065758) »

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